Seroatlas · Human Serome Atlas

ABI1

Abl interactor 1

Also known as: ABI-1, ABI1_HUMAN, E3B1, SSH3BP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IZP0
Gene
ABI1
Ensembl
ENSG00000136754
Chromosome
10
Canonical length
508 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q8IZP0|ABI1
     1  MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS
    61  VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR
   121  THKIIAPANM ERPVRYIRKP IDYTVLDDVG HGVKWLKAKH GNNQPARTGT LSRTNPPTQK
   181  PPSPPMSGRG TLGRNTPYKT LEPVKPPTVP NDYMTSPARL GSQHSPGRTA SLNQRPRTHS
   241  GSSGGSGSRE NSGSSSIGIP IAVPTPSPPT IGPENISVPP PSGAPPAPPL APLLPVSTVI
   301  AAPGSAPGSQ YGTMTRQISR HNSTTSSTSS GGYRRTPSVT AQFSAQPHVN GGPLYSQNSI
   361  SIAPPPPPMP QLTPQIPLTG FVARVQENIA DSPTPPPPPP PDDIPMFDDS PPPPPPPPVD
   421  YEDEEAAVVQ YNDPYADGDP AWAPKNYIEK VVAIYDYTKD KDDELSFMEG AIIYVIKKND
   481  DGWYEGVCNR VTGLFPGNYV ESIMHYTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
91 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 91 nTPM
  • tonsil: 63 nTPM
  • lymph node: 54 nTPM
  • esophagus: 53 nTPM
  • thymus: 50 nTPM
  • skin: 46 nTPM

Single-cell type

  • neutrophils: 771 nCPM
  • neutrophil progenitors: 762 nCPM
  • ocular epithelial cells: 729 nCPM
  • esophageal apical cells: 565 nCPM
  • suprabasal keratinocytes: 554 nCPM
  • basal keratinocytes: 539 nCPM

Immune cell

  • eosinophil: 137 nTPM
  • T-reg: 114 nTPM
  • basophil: 110 nTPM
  • neutrophil: 93 nTPM
  • memory B-cell: 85 nTPM
  • total PBMC: 85 nTPM

Brain region

  • hippocampal formation: 79 nTPM
  • cerebral cortex: 64 nTPM
  • basal ganglia: 55 nTPM
  • amygdala: 53 nTPM
  • hypothalamus: 53 nTPM
  • cerebellum: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.64
gnomAD missense Z
2.09
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABI1 as an antibody target. Whether an autoantibody or antibody against ABI1 could matter depends on whether native ABI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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