Seroatlas · Human Serome Atlas

LGI3

Leucine-rich repeat LGI family member 3

Also known as: LGI3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N145
Gene: LGI3
Ensembl: ENSG00000168481
Chromosome: 8
Canonical length: 548 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to be involved in regulation of exocytosis. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

548 residues, UniProt reviewed canonical sequence.

>Q8N145|LGI3
     1  MAGLRARGGP GPGLLALSAL GFCLMLQVSA KRPPKTPPCP PSCSCTRDTA FCVDSKAVPR
    61  NLPSEVISLT LVNAAFSEIQ DGAFSHLPLL QFLLLNSNKF TLIGDNAFTG LSHLQYLFIE
   121  NNDIWALSKF TFRGLKSLTH LSLANNNLQT LPRDIFRPLD ILNDLDLRGN SLNCDCKVKW
   181  LVEWLAHTNT TVAPIYCASP PRFQEHKVQD LPLREFDCIT TDFVLYQTLA FPAVSAEPFL
   241  YSSDLYLALA QPGVSACTIL KWDYVERQLR DYDRIPAPSA VHCKPMVVDS QLYVVVAQLF
   301  GGSYIYHWDP NTTRFTRLQD IDPQRVRKPN DLEAFRIDGD WYFAVADSSK AGATSLYRWH
   361  QNGFYSHQAL HPWHRDTDLE FVDGEGKPRL IVSSSSQAPV IYQWSRTQKQ FVAQGEVTQV
   421  PDAQAVKHFR AGRDSYLCLS RYIGDSKILR WEGTRFSEVQ ALPSRGSLAL QPFLVGGRRY
   481  LALGSDFSFT QIYQWDEGRQ KFVRFQELAV QAPRAFCYMP AGDAQLLLAP SFKGQTLVYR
   541  HIVVDLSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 95 nTPM
cerebral cortex: 75 nTPM
basal ganglia: 74 nTPM
midbrain: 69 nTPM
hippocampal formation: 59 nTPM
hypothalamus: 45 nTPM

Single-cell type

oligodendrocytes: 97 nCPM
melanocytes: 74 nCPM
alveolar cells type 2: 62 nCPM
brain inhibitory neurons: 20 nCPM
esophageal apical cells: 15 nCPM
other brain neurons: 15 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 224 nTPM
pons: 187 nTPM
thalamus: 177 nTPM
cerebral cortex: 172 nTPM
cerebellum: 168 nTPM
medulla oblongata: 163 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LGI3.

Disease | AllUniProt

Conditions LGI3 is implicated in, by any mechanism.

Intellectual developmental disorder with muscle tone abnormalities and distal skeletal defects (IDDMDS) MIM:620007

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 128 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Peripheral nerve hyperexcitability syndrome
Intellectual developmental disorder with muscle tone abnormalities and distal skeletal defects
Fetal anomalies with a likely genetic cause

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LGI3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STX1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LGI3 as an antibody target. Whether an autoantibody or antibody against LGI3 could matter depends on whether native LGI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LGI3 is annotated as secreted, so native LGI3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LGI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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