Seroatlas · Human Serome Atlas

CPLX1

Complexin-1

Also known as: CPLX1_HUMAN, CPX-I

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14810
Gene
CPLX1
Ensembl
ENSG00000168993
Chromosome
4
Canonical length
134 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>O14810|CPLX1
     1  MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE
    61  AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV
   121  IKYLPGPLQD MLKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPLX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
231 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 231 nTPM
  • basal ganglia: 200 nTPM
  • cerebellum: 151 nTPM
  • hippocampal formation: 86 nTPM
  • amygdala: 76 nTPM
  • midbrain: 72 nTPM

Single-cell type

  • retinal ganglion cells: 151 nCPM
  • brain inhibitory neurons: 89 nCPM
  • retinal amacrine cells: 68 nCPM
  • brain excitatory neurons: 64 nCPM
  • neuroendocrine cells: 45 nCPM
  • vascular endothelial cells: 43 nCPM

Immune cell

  • plasmacytoid DC: 0.3 nTPM
  • MAIT T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 773 nTPM
  • pons: 488 nTPM
  • thalamus: 464 nTPM
  • medulla oblongata: 425 nTPM
  • white matter: 384 nTPM
  • hypothalamus: 342 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CPLX1.

Disease | AllUniProt

Conditions CPLX1 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 63 (DEE63) MIM:617976

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.82
gnomAD missense Z
-0.35
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CPLX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CPLX1 as an antibody target. Whether an autoantibody or antibody against CPLX1 could matter depends on whether native CPLX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CPLX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CPLX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CPLX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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