Seroatlas · Human Serome Atlas

STXBP5L

Syntaxin-binding protein 5-like

Also known as: KIAA1006, LLGL4, STB5L_HUMAN, tomosyn-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2K9
Gene
STXBP5L
Ensembl
ENSG00000145087
Chromosome
3
Canonical length
1186 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is similar to syntaxin-binding protein 5 and contains ten N-terminal WD40 repeats, four variable region WD40 repeats, and a C-terminal R-SNARE domain. Studies of the orthologous proteins in mouse and rat have shown that the encoded protein may inhibit exocytosis in neurosecretory cells, and may negatively regulate the secretion of insulin. A missense variant in this gene is likely the cause of an infantile-onset neurodegenerative disorder diagnosed in two siblings of consanguineous parents. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

1186 residues, UniProt reviewed canonical sequence.

>Q9Y2K9|STXBP5L
     1  MKKFNFRKVL DGLTASSPGS GSSSGSNSGG GAGSGSVHPA GTAGVLREEI QETLTSEYFQ
    61  ICKTVRHGFP HQPTALAFDP VQKILAIGTR TGAIRILGRP GVDCYCQHES GAAVLQLQFL
   121  INEGALVSAS SDDTLHLWNL RQKRPAILHS LKFNRERITY CHLPFQSKWL YVGTERGNTH
   181  IVNIESFILS GYVIMWNKAI ELSTKTHPGP VVHLSDSPRD EGKLLIGYEN GTVVFWDLKS
   241  KRAELRVYYD EAIHSIDWHH EGKQFMCSHS DGSLTLWNLK SPSRPFQTTI PHGKSQREGR
   301  KSESCKPILK VEYKTCKNSE PFIIFSGGLS YDKACRRPSL TIMHGKAITV LEMDHPIVEF
   361  LTLCETPYPN EFQEPYAVVV LLEKDLIVVD LTQSNFPIFE NPYPMDIHES PVTCTAYFAD
   421  CPPDLILVLY SIGVKHKKQG YSNKEWPISG GAWNLGAQTY PEIIITGHAD GSIKFWDASA
   481  ITLQMLYKLK TSKVFEKQKV GEGKQTCEIV EEDPFAIQMI YWCPESRIFC VSGVSAYVII
   541  YKFSRHEITT EIVSLEVRLQ YDVEDIITPE PETSPPFPDL SAQLPSSRSL SGSTNTVASE
   601  GVTKDSIPCL NVKTRPVRMP PGYQAELVIQ LVWVDGEPPQ QITSLAVSSA YGIVAFGNCN
   661  GLAVVDFIQK TVLLSMGTID LYRSSDLYQR QPRSPRKNKQ FIADNFCMRG LSNFYPDLTK
   721  RIRTSYQSLT ELNDSPVPLE LERCKSPTSD HVNGHCTSPT SQSCSSGKRL SSADVSKVNR
   781  WGPGRPPFRK AQSAACMEIS LPVTTEENRE NSYNRSRSSS ISSIDKDSKE AITALYFMDS
   841  FARKNDSTIS PCLFVGTSLG MVLIISLNLP LADEQRFTEP VMVLPSGTFL SLKGAVLTFS
   901  CMDRMGGLMQ PPYEVWRDPN NIDENEKSWR RKVVMNSSSA SQEIGDHQYT IICSEKQAKV
   961  FSLPSQTCLY VHNITETSFI LQANVVVMCS SACLACFCAN GHIMIMSLPS LRPMLDVNYL
  1021  PLTDMRIART FCFTNEGQAL YLVSPTEIQR LTYSQEMCDN LQDMLGDLFT PIETPEAQNR
  1081  GFLKGLFGGS GQTFDREELF GEASAGKASR SLAQHIPGPG SIEGMKGAAG GVMGELTRAR
  1141  IALDERGQRL GELEEKTAGM MTSAEAFSKH AHELMLKYKD KKWYQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STXBP5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 24 nTPM
  • cerebral cortex: 8.6 nTPM
  • thyroid gland: 7.1 nTPM
  • ovary: 5.8 nTPM
  • hippocampal formation: 4.1 nTPM
  • retina: 4 nTPM

Single-cell type

  • brain excitatory neurons: 2,145 nCPM
  • brain inhibitory neurons: 966 nCPM
  • thyrotrophs: 740 nCPM
  • lactotrophs: 717 nCPM
  • somatotrophs: 595 nCPM
  • corticotrophs: 579 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 215 nTPM
  • cerebral cortex: 126 nTPM
  • hippocampal formation: 108 nTPM
  • white matter: 81 nTPM
  • pons: 75 nTPM
  • basal ganglia: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
1
gnomAD missense Z
1.71
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STXBP5L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STXBP5L as an antibody target. Whether an autoantibody or antibody against STXBP5L could matter depends on whether native STXBP5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STXBP5L is annotated at the cell surface, where native STXBP5L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STXBP5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STXBP5L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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