Seroatlas · Human Serome Atlas

NAPB

Beta-soluble NSF attachment protein

Also known as: SNAB_HUMAN, SNAP-BETA, SNAPB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H115
Gene
NAPB
Ensembl
ENSG00000125814
Chromosome
20
Canonical length
298 aa
Protein class
Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>Q9H115|NAPB
     1  MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN MFKMAKNWSA
    61  AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA INCLNAAIDI YTDMGRFTIA
   121  AKHHITIAEI YETELVDIEK AIAHYEQSAD YYKGEESNSS ANKCLLKVAA YAAQLEQYQK
   181  AIEIYEQVGA NTMDNPLLKY SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE
   241  CKLLKKLLEA HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NAPB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
190 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 190 nTPM
  • cerebellum: 150 nTPM
  • retina: 143 nTPM
  • amygdala: 106 nTPM
  • hypothalamus: 103 nTPM
  • hippocampal formation: 97 nTPM

Single-cell type

  • choroid plexus epithelial cells: 168 nCPM
  • retinal bipolar cells: 167 nCPM
  • sertoli cells: 106 nCPM
  • retinal amacrine cells: 98 nCPM
  • cone photoreceptor cells: 97 nCPM
  • late spermatids: 97 nCPM

Immune cell

  • basophil: 2.5 nTPM
  • gdT-cell: 1.9 nTPM
  • naive B-cell: 1.2 nTPM
  • naive CD8 T-cell: 1.2 nTPM
  • T-reg: 1 nTPM
  • memory CD8 T-cell: 0.9 nTPM

Brain region

  • cerebral cortex: 290 nTPM
  • hypothalamus: 225 nTPM
  • pons: 216 nTPM
  • basal ganglia: 213 nTPM
  • white matter: 198 nTPM
  • hippocampal formation: 170 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NAPB.

Disease | AllUniProt

Conditions NAPB is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 107 (DEE107) MIM:620033

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 52 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Developmental and epileptic encephalopathy-107

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0.11
gnomAD missense Z
1.6
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NAPB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NAPB as an antibody target. Whether an autoantibody or antibody against NAPB could matter depends on whether native NAPB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NAPB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NAPB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NAPB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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