Seroatlas · Human Serome Atlas

SYBU

Syntabulin

Also known as: FLJ20366, GOLSYN, KIAA1472, OCSYN, SNPHL, SYBU_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NX95
Gene
SYBU
Ensembl
ENSG00000147642
Chromosome
8
Canonical length
663 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

663 residues, UniProt reviewed canonical sequence.

>Q9NX95|SYBU
     1  MGPLRESKKE HRVQHHDKEI SRSRIPRLIL RPHMPQQQHK VSPASESPFS EEESREFNPS
    61  SSGRSARTVS SNSFCSDDTG CPSSQSVSPV KTPSDAGNSP IGFCPGSDEG FTRKKCTIGM
   121  VGEGSIQSSR YKKESKSGLV KPGSEADFSS SSSTGSISAP EVHMSTAGSK RSSSSRNRGP
   181  HGRSNGASSH KPGSSPSSPR EKDLLSMLCR NQLSPVNIHP SYAPSSPSSS NSGSYKGSDC
   241  SPIMRRSGRY MSCGENHGVR PPNPEQYLTP LQQKEVTVRH LKTKLKESER RLHERESEIV
   301  ELKSQLARMR EDWIEEECHR VEAQLALKEA RKEIKQLKQV IETMRSSLAD KDKGIQKYFV
   361  DINIQNKKLE SLLQSMEMAH SGSLRDELCL DFPCDSPEKS LTLNPPLDTM ADGLSLEEQV
   421  TGEGADRELL VGDSIANSTD LFDEIVTATT TESGDLELVH STPGANVLEL LPIVMGQEEG
   481  SVVVERAVQT DVVPYSPAIS ELIQSVLQKL QDPCPSSLAS PDESEPDSME SFPESLSALV
   541  VDLTPRNPNS AILLSPVETP YANVDAEVHA NRLMRELDFA ACVEERLDGV IPLARGGVVR
   601  QYWSSSFLVD LLAVAAPVVP TVLWAFSTQR GGTDPVYNIG ALLRGCCVVA LHSLRRTAFR
   661  IKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYBU can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
133 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 133 nTPM
  • cerebellum: 93 nTPM
  • cerebral cortex: 65 nTPM
  • hypothalamus: 57 nTPM
  • basal ganglia: 56 nTPM
  • liver: 48 nTPM

Single-cell type

  • lactotrophs: 415 nCPM
  • brain excitatory neurons: 255 nCPM
  • brain inhibitory neurons: 238 nCPM
  • thyrotrophs: 236 nCPM
  • other brain neurons: 230 nCPM
  • retinal horizontal cells: 222 nCPM

Immune cell

  • memory B-cell: 6.5 nTPM
  • naive B-cell: 3.2 nTPM
  • T-reg: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • hypothalamus: 136 nTPM
  • cerebral cortex: 120 nTPM
  • cerebellum: 106 nTPM
  • basal ganglia: 99 nTPM
  • pons: 92 nTPM
  • amygdala: 90 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0
gnomAD missense Z
1.08
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYBU in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYBU as an antibody target. Whether an autoantibody or antibody against SYBU could matter depends on whether native SYBU is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYBU is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYBU as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SYBU. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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