Syntaxin/epimorphin, conserved site
IPR006012
Definition
Syntaxins A and B are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins are a family of receptors for intracellular transport vesicles. Each target membrane may be identified by a specific member of the syntaxin family PMID:7690687. Members of the syntaxin family [[cite:PMID:8493722], [cite:PMID:8490959]] have a size ranging from 30 Kd to 40 Kd; a C-terminal extremity which is highly hydrophobic and anchors the protein on the cytoplasmic surface of cellular membranes; a central, well conserved region SNARE motif, which seems to be in a coiled-coil conformation. SNARE motifs assemble into parallel four helix bundles stabilised by the burial of these hydrophobic helix faces in the bundle core PMID:14570579. Monomeric SNARE motifs are disordered so this assembly reaction is accompanied by a dramatic increase in α-helical secondary structure. The parallel arrangement of SNARE motifs within complexes bring the transmembrane anchors, and the two membranes, into close proximity.
15 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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