Seroatlas · Human Serome Atlas

CAV1

Caveolin-1

Also known as: CAV, CAV1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03135
Gene
CAV1
Ensembl
ENSG00000105974
Chromosome
7
Canonical length
178 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Perinuclear theca,Connecting piece,Principal piece
Quaternary structure
Homooligomer

OverviewNCBI Gene

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>Q03135|CAV1
     1  MSGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMADELSEKQ VYDAHTKEID LVNRDPKHLN
    61  DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA
   121  ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTVCDPLF EAVGKIFSNV RINLQKEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
583 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 583 nTPM
  • lung: 558 nTPM
  • placenta: 422 nTPM
  • blood vessel: 320 nTPM
  • colon: 287 nTPM
  • breast: 284 nTPM

Single-cell type

  • alveolar cells type 1: 1,961 nCPM
  • basal keratinocytes: 1,117 nCPM
  • smooth muscle cells: 1,110 nCPM
  • vascular endothelial cells: 943 nCPM
  • transitional alveolar cells: 881 nCPM
  • vascular smooth muscle cells: 828 nCPM

Immune cell

  • basophil: 15 nTPM
  • memory B-cell: 5.1 nTPM
  • naive B-cell: 0.9 nTPM
  • total PBMC: 0.9 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM

Brain region

  • thalamus: 16 nTPM
  • white matter: 15 nTPM
  • medulla oblongata: 14 nTPM
  • basal ganglia: 14 nTPM
  • pons: 13 nTPM
  • spinal cord: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAV1.

Disease | AllUniProt

Conditions CAV1 is implicated in, by any mechanism.

  • Lipodystrophy, congenital generalized, 3 (CGL3) MIM:612526
  • Pulmonary hypertension, primary, 3 (PPH3) MIM:615343
  • Lipodystrophy, familial partial, 7 (FPLD7) MIM:606721

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 194 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Partial lipodystrophy, congenital cataracts, and neurodegeneration syndrome
  • Pulmonary hypertension, primary, 3
  • Congenital generalized lipodystrophy type 3
  • Inborn genetic diseases
  • CAV1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.31
gnomAD pLI
0.01
gnomAD missense Z
0.67
DepMap mean gene effect
0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAV1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAV1 as an antibody target. Whether an autoantibody or antibody against CAV1 could matter depends on whether native CAV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAV1 is annotated at the cell surface, where native CAV1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CAV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAV1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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