SEC22B
Vesicle-trafficking protein SEC22b
Also known as: ERS-24, SC22B_HUMAN, SEC22L1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75396
- Gene
- SEC22B
- Ensembl
- ENSG00000265808
- Chromosome
- 1
- Canonical length
- 215 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
OverviewNCBI Gene
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]
Canonical amino-acid sequenceUniProt
215 residues, UniProt reviewed canonical sequence.
>O75396|SEC22B
1 MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT RCTLEAGAMT
61 FHYIIEQGVC YLVLCEAAFP KKLAFAYLED LHSEFDEQHG KKVPTVSRPY SFIEFDTFIQ
121 KTKKLYIDSR ARRNLGSINT ELQDVQRIMV ANIEEVLQRG EALSALDSKA NNLSSLSKKY
181 RQDAKYLNMR STYAKLAAVA VFFIMLIVYV RFWWLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SEC22B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 55 nTPM
Expression across tissuesHPA
Tissue
- retina: 55 nTPM
- epididymis: 33 nTPM
- liver: 32 nTPM
- pituitary gland: 28 nTPM
- salivary gland: 27 nTPM
- pancreas: 24 nTPM
Single-cell type
- neutrophils: 165 nCPM
- rod photoreceptor cells: 105 nCPM
- mucous neck cells: 80 nCPM
- epididymal principal cells: 77 nCPM
- gastric chief cells: 76 nCPM
- breast lactating cells: 73 nCPM
Immune cell
- neutrophil: 29 nTPM
- basophil: 23 nTPM
- MAIT T-cell: 20 nTPM
- plasmacytoid DC: 19 nTPM
- naive CD8 T-cell: 19 nTPM
- classical monocyte: 18 nTPM
Brain region
- white matter: 33 nTPM
- choroid plexus: 31 nTPM
- cerebellum: 30 nTPM
- hypothalamus: 29 nTPM
- thalamus: 29 nTPM
- midbrain: 28 nTPM
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- endoplasmic reticulum to Golgi vesicle-mediated transport
- negative regulation of autophagosome assembly
- positive regulation of protein catabolic process
- protein transport
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SEC22B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SEC22B as an antibody target. Whether an autoantibody or antibody against SEC22B could matter depends on whether native SEC22B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SEC22B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SEC22B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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