Seroatlas · Human Serome Atlas

PPP1R16B

Protein phosphatase 1 regulatory inhibitor subunit 16B

Also known as: ANKRD4, KIAA0823, PP16B_HUMAN, TIMAP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96T49
Gene
PPP1R16B
Ensembl
ENSG00000101445
Chromosome
20
Canonical length
567 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nuclear speckles,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>Q96T49|PPP1R16B
     1  MASHVDLLTE LQLLEKVPTL ERLRAAQKRR AQQLKKWAQY EQDLQHRKRK HERKRSTGGR
    61  RKKVSFEASV ALLEASLRND AEEVRYFLKN KVSPDLCNED GLTALHQCCI DNFEEIVKLL
   121  LSHGANVNAK DNELWTPLHA AATCGHINLV KILVQYGADL LAVNSDGNMP YDLCEDEPTL
   181  DVIETCMAYQ GITQEKINEM RVAPEQQMIA DIHCMIAAGQ DLDWIDAQGA TLLHIAGANG
   241  YLRAAELLLD HGVRVDVKDW DGWEPLHAAA FWGQMQMAEL LVSHGASLSA RTSMDEMPID
   301  LCEEEEFKVL LLELKHKHDV IMKSQLRHKS SLSRRTSSAG SRGKVVRRAS LSDRTNLYRK
   361  EYEGEAILWQ RSAAEDQRTS TYNGDIRETR TDQENKDPNP RLEKPVLLSE FPTKIPRGEL
   421  DMPVENGLRA PVSAYQYALA NGDVWKVHEV PDYSMAYGNP GVADATPPWS SYKEQSPQTL
   481  LELKRQRAAA KLLSHPFLST HLGSSMARTG ESSSEGKAPL IGGRTSPYSS NGTSVYYTVT
   541  SGDPPLLKFK APIEEMEEKV HGCCRIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R16B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 73 nTPM
  • cerebral cortex: 69 nTPM
  • amygdala: 46 nTPM
  • hippocampal formation: 45 nTPM
  • tonsil: 39 nTPM
  • lymph node: 35 nTPM

Single-cell type

  • t-cells: 570 nCPM
  • nk-cells: 516 nCPM
  • thymocytes: 448 nCPM
  • oligodendrocytes: 422 nCPM
  • pdcs: 410 nCPM
  • innate lymphoid cells: 368 nCPM

Immune cell

  • memory B-cell: 5.3 nTPM
  • gdT-cell: 3.4 nTPM
  • naive B-cell: 3.4 nTPM
  • memory CD8 T-cell: 3.3 nTPM
  • plasmacytoid DC: 3.3 nTPM
  • NK-cell: 2.9 nTPM

Brain region

  • basal ganglia: 145 nTPM
  • cerebral cortex: 121 nTPM
  • white matter: 104 nTPM
  • hippocampal formation: 76 nTPM
  • amygdala: 72 nTPM
  • thalamus: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.17
gnomAD pLI
1
gnomAD missense Z
2.44
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R16B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R16B as an antibody target. Whether an autoantibody or antibody against PPP1R16B could matter depends on whether native PPP1R16B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R16B is annotated at the cell surface, where native PPP1R16B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PPP1R16B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP1R16B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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