Seroatlas · Human Serome Atlas

MLEC

Malectin

Also known as: KIAA0152, MLEC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14165
Gene
MLEC
Ensembl
ENSG00000110917
Chromosome
12
Canonical length
292 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>Q14165|MLEC
     1  MLGAWAVEGT AVALLRLLLL LLPPAIRGPG LGVAGVAGAA GAGLPESVIW AVNAGGEAHV
    61  DVHGIHFRKD PLEGRVGRAS DYGMKLPILR SNPEDQILYQ TERYNEETFG YEVPIKEEGD
   121  YVLVLKFAEV YFAQSQQKVF DVRLNGHVVV KDLDIFDRVG HSTAHDEIIP MSIRKGKLSV
   181  QGEVSTFTGK LYIEFVKGYY DNPKVCALYI MAGTVDDVPK LQPHPGLEKK EEEEEEEEYD
   241  EGSNLKKQTN KNRVQSGPRT PNPYASDNSS LMFPILVAFG VFIPTLFCLC RL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MLEC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
130 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 130 nTPM
  • colon: 119 nTPM
  • rectum: 110 nTPM
  • parathyroid gland: 95 nTPM
  • thyroid gland: 95 nTPM
  • adrenal gland: 93 nTPM

Single-cell type

  • melanocytes: 434 nCPM
  • epididymal principal cells: 394 nCPM
  • enteric stem cells: 382 nCPM
  • enteric transient amplifying cells: 371 nCPM
  • paneth cells: 317 nCPM
  • late spermatids: 255 nCPM

Immune cell

  • plasmacytoid DC: 19 nTPM
  • eosinophil: 8 nTPM
  • intermediate monocyte: 7.5 nTPM
  • naive B-cell: 6.9 nTPM
  • non-classical monocyte: 6.5 nTPM
  • classical monocyte: 6 nTPM

Brain region

  • medulla oblongata: 71 nTPM
  • hypothalamus: 71 nTPM
  • spinal cord: 66 nTPM
  • choroid plexus: 66 nTPM
  • thalamus: 66 nTPM
  • midbrain: 65 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.61
gnomAD missense Z
2.16
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Malectin domain
  • Malectin
  • Malectin domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MLEC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MLEC as an antibody target. Whether an autoantibody or antibody against MLEC could matter depends on whether native MLEC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MLEC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MLEC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MLEC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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