HSP90B1

Protein identityUniProt · HPA

UniProt accession

P14625

Gene

HSP90B1

Ensembl

ENSG00000166598

Chromosome

12

Canonical length

803 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Endoplasmic reticulum

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

803 residues, UniProt reviewed canonical sequence.

>P14625|HSP90B1
     1  MRALWVLGLC CVLLTFGSVR ADDEVDVDGT VEEDLGKSRE GSRTDDEVVQ REEEAIQLDG
    61  LNASQIRELR EKSEKFAFQA EVNRMMKLII NSLYKNKEIF LRELISNASD ALDKIRLISL
   121  TDENALSGNE ELTVKIKCDK EKNLLHVTDT GVGMTREELV KNLGTIAKSG TSEFLNKMTE
   181  AQEDGQSTSE LIGQFGVGFY SAFLVADKVI VTSKHNNDTQ HIWESDSNEF SVIADPRGNT
   241  LGRGTTITLV LKEEASDYLE LDTIKNLVKK YSQFINFPIY VWSSKTETVE EPMEEEEAAK
   301  EEKEESDDEA AVEEEEEEKK PKTKKVEKTV WDWELMNDIK PIWQRPSKEV EEDEYKAFYK
   361  SFSKESDDPM AYIHFTAEGE VTFKSILFVP TSAPRGLFDE YGSKKSDYIK LYVRRVFITD
   421  DFHDMMPKYL NFVKGVVDSD DLPLNVSRET LQQHKLLKVI RKKLVRKTLD MIKKIADDKY
   481  NDTFWKEFGT NIKLGVIEDH SNRTRLAKLL RFQSSHHPTD ITSLDQYVER MKEKQDKIYF
   541  MAGSSRKEAE SSPFVERLLK KGYEVIYLTE PVDEYCIQAL PEFDGKRFQN VAKEGVKFDE
   601  SEKTKESREA VEKEFEPLLN WMKDKALKDK IEKAVVSQRL TESPCALVAS QYGWSGNMER
   661  IMKAQAYQTG KDISTNYYAS QKKTFEINPR HPLIRDMLRR IKEDEDDKTV LDLAVVLFET
   721  ATLRSGYLLP DTKAYGDRIE RMLRLSLNID PDAKVEEEPE EEPEETAEDT TEDTEQDEDE
   781  EMDVGTDEEE ETAKESTAEK DEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSP90B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

1,323 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSP90B1.

Disease | ImmuneIEDB

Conditions an epitope on HSP90B1 was assayed in.

• type 1 diabetes mellitus T cell
• acute myeloid leukemia T cell

ReferencesPubMed · IEDB

Publications for HSP90B1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.27

gnomAD pLI

1

gnomAD missense Z

2.12

DepMap mean gene effect

-0.61

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin rod assembly
• cellular response to ATP
• cellular response to manganese ion
• ERAD pathway
• negative regulation of apoptotic process
• positive regulation of toll-like receptor signaling pathway
• positive regulation of Wnt signaling pathway
• protein folding
• protein folding in endoplasmic reticulum
• protein localization to plasma membrane
• protein transport
• response to endoplasmic reticulum stress
• response to hypoxia
• retrograde protein transport, ER to cytosol
• sequestering of calcium ion

Molecular functions

• ATP binding
• ATP hydrolysis activity
• ATP-dependent protein folding chaperone
• calcium ion binding
• low-density lipoprotein particle receptor binding
• protein folding chaperone
• protein phosphatase binding
• protein phosphatase inhibitor activity
• RNA binding
• unfolded protein binding

Cellular components

• cytosol
• endocytic vesicle lumen
• endoplasmic reticulum
• endoplasmic reticulum chaperone complex
• endoplasmic reticulum lumen
• endoplasmic reticulum membrane
• extracellular exosome
• extracellular region
• focal adhesion
• melanosome
• membrane
• midbody
• nucleus
• perinuclear region of cytoplasm
• protein-containing complex
• sarcoplasmic reticulum lumen
• smooth endoplasmic reticulum
• sperm plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Heat shock protein Hsp90 family
• Histidine kinase/HSP90-like ATPase domain
• Heat shock protein Hsp90, conserved site
• Ribosomal protein uS5 domain 2-type superfamily
• Heat shock protein Hsp90, N-terminal
• Histidine kinase/HSP90-like ATPase superfamily
• HSP90, C-terminal domain
• Hsp90 protein
• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

KeywordsUniProt

• Acetylation
• ATP-binding
• Calcium
• Chaperone
• Disulfide bond
• Endoplasmic reticulum
• Glycoprotein
• Hydrolase
• Hydroxylation
• Nucleotide-binding
• Phosphoprotein
• Sarcoplasmic reticulum
• Signal

InteractionsUniProt · HPA

Protein binding partners of HSP90B1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• AIMP1
• CNPY3
• EIF2AK3
• IL1B
• METTL23
• MZB1
• OS9
• TLR4
• TLR9
• CANX
• DDOST
• EGFR
• FANCC
• HSP90AA1
• HSPA5
• RPN1
• RPN2