Seroatlas · Human Serome Atlas

TMPO

Lamina-associated polypeptide 2, isoform alpha

Also known as: LAP2, LAP2A_HUMAN, LEMD4, TP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P42166
Gene
TMPO
Ensembl
ENSG00000120802
Chromosome
12
Canonical length
694 aa
Protein class
Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear membrane

OverviewNCBI Gene

Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]

Canonical amino-acid sequenceUniProt

694 residues, UniProt reviewed canonical sequence.

>P42166|TMPO
     1  MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK
    61  GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL
   121  LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS
   181  DRYSDNEEGK KKEHKKVKST RDIVPFSELG TTPSGGGFFQ GISFPEISTR PPLGSTELQA
   241  AKKVHTSKGD LPREPLVATN LPGRGQLQKL ASERNLFISC KSSHDRCLEK SSSSSSQPEH
   301  SAMLVSTAAS PSLIKETTTG YYKDIVENIC GREKSGIQPL CPERSHISDQ SPLSSKRKAL
   361  EESESSQLIS PPLAQAIRDY VNSLLVQGGV GSLPGTSNSM PPLDVENIQK RIDQSKFQET
   421  EFLSPPRKVP RLSEKSVEER DSGSFVAFQN IPGSELMSSF AKTVVSHSLT TLGLEVAKQS
   481  QHDKIDASEL SFPFHESILK VIEEEWQQVD RQLPSLACKY PVSSREATQI LSVPKVDDEI
   541  LGFISEATPL GGIQAASTES CNQQLDLALC RAYEAAASAL QIATHTAFVA KAMQADISQA
   601  AQILSSDPSR THQALGILSK TYDAASYICE AAFDEVKMAA HTMGNATVGR RYLWLKDCKI
   661  NLASKNKLAS TPFKGGTLFG GEVCKVIKKR GNKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMPO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
130 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 130 nTPM
  • bone marrow: 88 nTPM
  • lymph node: 74 nTPM
  • tonsil: 73 nTPM
  • ovary: 47 nTPM
  • appendix: 42 nTPM

Single-cell type

  • monocyte progenitors: 511 nCPM
  • erythrocyte progenitors: 361 nCPM
  • megakaryocyte progenitors: 283 nCPM
  • megakaryocyte-erythroid progenitors: 149 nCPM
  • monocytes: 149 nCPM
  • neutrophil progenitors: 140 nCPM

Immune cell

  • non-classical monocyte: 76 nTPM
  • intermediate monocyte: 54 nTPM
  • basophil: 49 nTPM
  • classical monocyte: 30 nTPM
  • total PBMC: 30 nTPM
  • naive CD4 T-cell: 30 nTPM

Brain region

  • cerebellum: 47 nTPM
  • white matter: 37 nTPM
  • cerebral cortex: 32 nTPM
  • choroid plexus: 29 nTPM
  • medulla oblongata: 28 nTPM
  • thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1
gnomAD pLI
0
gnomAD missense Z
-0.61
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMPO in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMPO as an antibody target. Whether an autoantibody or antibody against TMPO could matter depends on whether native TMPO is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMPO is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMPO as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMPO. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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