STT3A

Protein identityUniProt · HPA

UniProt accession

P46977

Gene

STT3A

Ensembl

ENSG00000134910

Chromosome

11

Canonical length

705 aa

Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

705 residues, UniProt reviewed canonical sequence.

>P46977|STT3A
     1  MTKFGFLRLS YEKQDTLLKL LILSMAAVLS FSTRLFAVLR FESVIHEFDP YFNYRTTRFL
    61  AEEGFYKFHN WFDDRAWYPL GRIIGGTIYP GLMITSAAIY HVLHFFHITI DIRNVCVFLA
   121  PLFSSFTTIV TYHLTKELKD AGAGLLAAAM IAVVPGYISR SVAGSYDNEG IAIFCMLLTY
   181  YMWIKAVKTG SICWAAKCAL AYFYMVSSWG GYVFLINLIP LHVLVLMLTG RFSHRIYVAY
   241  CTVYCLGTIL SMQISFVGFQ PVLSSEHMAA FGVFGLCQIH AFVDYLRSKL NPQQFEVLFR
   301  SVISLVGFVL LTVGALLMLT GKISPWTGRF YSLLDPSYAK NNIPIIASVS EHQPTTWSSY
   361  YFDLQLLVFM FPVGLYYCFS NLSDARIFII MYGVTSMYFS AVMVRLMLVL APVMCILSGI
   421  GVSQVLSTYM KNLDISRPDK KSKKQQDSTY PIKNEVASGM ILVMAFFLIT YTFHSTWVTS
   481  EAYSSPSIVL SARGGDGSRI IFDDFREAYY WLRHNTPEDA KVMSWWDYGY QITAMANRTI
   541  LVDNNTWNNT HISRVGQAMA STEEKAYEIM RELDVSYVLV IFGGLTGYSS DDINKFLWMV
   601  RIGGSTDTGK HIKENDYYTP TGEFRVDREG SPVLLNCLMY KMCYYRFGQV YTEAKRPPGF
   661  DRVRNAEIGN KDFELDVLEE AYTTEHWLVR IYKVKDLDNR GLSRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STT3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

13

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

369 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STT3A.

Disease | AllUniProt

Conditions STT3A is implicated in, by any mechanism.

• Congenital disorder of glycosylation 1W, autosomal recessive (CDG1WAR) MIM:615596
• Congenital disorder of glycosylation 1W, autosomal dominant (CDG1WAD) MIM:619714

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 288 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital disorder of glycosylation, type Iw, autosomal dominant
• STT3A-congenital disorder of glycosylation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.49

gnomAD pLI

0

gnomAD missense Z

3.62

DepMap mean gene effect

-0.25

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• post-translational protein modification
• protein N-linked glycosylation
• protein N-linked glycosylation via asparagine

Molecular functions

• dolichyl-diphosphooligosaccharide-protein glycotransferase activity
• metal ion binding

Cellular components

• endoplasmic reticulum membrane
• membrane
• oligosaccharyltransferase complex
• oligosaccharyltransferase complex A

Protein domainsUniProt · Pfam · InterPro

• Oligosaccharyl transferase, STT3 subunit
• Oligosaccharyl transferase STT3, N-terminal domain
• Oligosaccharyl transferase STT3, N-terminal
• AglB-like, core domain
• AglB core domain

KeywordsUniProt

• Congenital disorder of glycosylation
• Endoplasmic reticulum
• Glycoprotein
• Glycosyltransferase
• Magnesium
• Manganese
• Membrane
• Metal-binding
• Transferase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of STT3A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DDOST
• IRAK2
• POMK
• RPN1
• RPN2
• STING1