FAM241A
Uncharacterized protein FAM241A
Also known as: C4orf32, F241A_HUMAN, FLJ39370
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N8J7
- Gene
- FAM241A
- Ensembl
- ENSG00000174749
- Chromosome
- 4
- Canonical length
- 132 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Golgi apparatus
OverviewNCBI Gene
Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
132 residues, UniProt reviewed canonical sequence.
>Q8N8J7|FAM241A
1 MCSAGELLRG GDGGERDEDG DALAEREAAG TGWDPGASPR RRGQRPKESE QDVEDSQNHT
61 GEPVGDDYKK MGTLFGELNK NLINMGFTRM YFGERIVEPV IVIFFWVMLW FLGLQALGLV
121 AVLCLVIIYV QQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against FAM241A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 16 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 16 nTPM
- breast: 11 nTPM
- placenta: 10 nTPM
- retina: 8.9 nTPM
- salivary gland: 8.2 nTPM
- stomach: 6.8 nTPM
Single-cell type
- vascular endothelial cells: 254 nCPM
- breast lactating cells: 237 nCPM
- breast hormone-responsive cells: 176 nCPM
- thymocytes: 159 nCPM
- innate lymphoid cells: 157 nCPM
- lymphatic endothelial cells: 135 nCPM
Immune cell
- basophil: 2.7 nTPM
- neutrophil: 1.4 nTPM
- plasmacytoid DC: 1 nTPM
- naive B-cell: 0.8 nTPM
- classical monocyte: 0.6 nTPM
- eosinophil: 0.6 nTPM
Brain region
- cerebellum: 101 nTPM
- cerebral cortex: 99 nTPM
- white matter: 94 nTPM
- basal ganglia: 87 nTPM
- amygdala: 78 nTPM
- hippocampal formation: 78 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.85
- gnomAD pLI
- 0.66
- DepMap mean gene effect
- 0.07
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of FAM241A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads FAM241A as an antibody target. Whether an autoantibody or antibody against FAM241A could matter depends on whether native FAM241A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
FAM241A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label FAM241A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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