Seroatlas · Human Serome Atlas

VRK2

Serine/threonine-protein kinase VRK2

Also known as: VRK2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86Y07
Gene
VRK2
Ensembl
ENSG00000028116
Chromosome
2
Canonical length
508 aa
Protein class
Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

508 residues, UniProt reviewed canonical sequence.

>Q86Y07|VRK2
     1  MPPKRNEKYK LPIPFPEGKV LDDMEGNQWV LGKKIGSGGF GLIYLAFPTN KPEKDARHVV
    61  KVEYQENGPL FSELKFYQRV AKKDCIKKWI ERKQLDYLGI PLFYGSGLTE FKGRSYRFMV
   121  MERLGIDLQK ISGQNGTFKK STVLQLGIRM LDVLEYIHEN EYVHGDIKAA NLLLGYKNPD
   181  QVYLADYGLS YRYCPNGNHK QYQENPRKGH NGTIEFTSLD AHKGVALSRR SDVEILGYCM
   241  LRWLCGKLPW EQNLKDPVAV QTAKTNLLDE LPQSVLKWAP SGSSCCEIAQ FLVCAHSLAY
   301  DEKPNYQALK KILNPHGIPL GPLDFSTKGQ SINVHTPNSQ KVDSQKAATK QVNKAHNRLI
   361  EKKVHSERSA ESCATWKVQK EEKLIGLMNN EAAQESTRRR QKYQESQEPL NEVNSFPQKI
   421  SYTQFPNSFY EPHQDFTSPD IFKKSRSPSW YKYTSTVSTG ITDLESSTGL WPTISQFTLS
   481  EETNADVYYY RIIIPVLLML VFLALFFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VRK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 24 nTPM
  • lymph node: 19 nTPM
  • smooth muscle: 17 nTPM
  • esophagus: 17 nTPM
  • pancreas: 17 nTPM
  • appendix: 17 nTPM

Single-cell type

  • cardiomyocytes: 578 nCPM
  • oligodendrocytes: 495 nCPM
  • erythrocyte progenitors: 185 nCPM
  • adrenal medulla cells: 170 nCPM
  • epicardial cells: 164 nCPM
  • myonuclei: 159 nCPM

Immune cell

  • eosinophil: 35 nTPM
  • non-classical monocyte: 34 nTPM
  • naive B-cell: 32 nTPM
  • intermediate monocyte: 31 nTPM
  • memory B-cell: 30 nTPM
  • basophil: 29 nTPM

Brain region

  • white matter: 83 nTPM
  • basal ganglia: 54 nTPM
  • medulla oblongata: 51 nTPM
  • midbrain: 44 nTPM
  • pons: 41 nTPM
  • cerebral cortex: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
-0.95
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VRK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VRK2 as an antibody target. Whether an autoantibody or antibody against VRK2 could matter depends on whether native VRK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VRK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VRK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VRK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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