Seroatlas · Human Serome Atlas

KRTCAP2

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

Also known as: KCP2, KTAP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6L1
Gene: KRTCAP2
Ensembl: ENSG00000163463
Chromosome: 1
Canonical length: 136 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Enables enzyme activator activity and protein-macromolecule adaptor activity. Involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

136 residues, UniProt reviewed canonical sequence.

>Q8N6L1|KRTCAP2
     1  MVVGTGTSLA LSSLLSLLLF AGMQMYSRQL ASTEWLTIQG GLLGSGLFVF SLTAFNNLEN
    61  LVFGKGFQAK IFPEILLCLL LALFASGLIH RVCVTTCFIF SMVGLYYINK ISSTLYQAAA
   121  PVLTPAKVTG KSKKRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTCAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 425 nTPM

Expression across tissuesHPA

Tissue

pancreas: 425 nTPM
epididymis: 292 nTPM
choroid plexus: 266 nTPM
liver: 238 nTPM
testis: 228 nTPM
stomach: 226 nTPM

Single-cell type

gastric chief cells: 286 nCPM
parietal cells: 198 nCPM
plasma cells: 131 nCPM
late primary spermatocytes: 125 nCPM
epididymal principal cells: 120 nCPM
enterocytes: 91 nCPM

Immune cell

plasmacytoid DC: 843 nTPM
basophil: 661 nTPM
T-reg: 515 nTPM
MAIT T-cell: 506 nTPM
memory B-cell: 500 nTPM
memory CD4 T-cell: 500 nTPM

Brain region

white matter: 101 nTPM
medulla oblongata: 101 nTPM
cerebellum: 92 nTPM
hypothalamus: 90 nTPM
pons: 84 nTPM
choroid plexus: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: -0.42
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Keratinocyte-associated protein 2
Keratinocyte-associated protein 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRTCAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTCAP2 as an antibody target. Whether an autoantibody or antibody against KRTCAP2 could matter depends on whether native KRTCAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTCAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTCAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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