Seroatlas · Human Serome Atlas

EMC2

ER membrane protein complex subunit 2

Also known as: EMC2_HUMAN, KIAA0103, TTC35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15006
Gene
EMC2
Ensembl
ENSG00000104412
Chromosome
8
Canonical length
297 aa
Protein class
Predicted intracellular proteins, Transporters

OverviewNCBI Gene

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Is extrinsic component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q15006|EMC2
     1  MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL INEYASKLGD DIWIIYEQVM
    61  IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM ERYDDAIQLY DRILQEDPTN
   121  TAARKRKIAI RKAQGKNVEA IRELNEYLEQ FVGDQEAWHE LAELYINEHD YAKAAFCLEE
   181  LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA
   241  SNPKASAKTK KDNMKYASWA ASQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 26 nTPM
  • midbrain: 21 nTPM
  • choroid plexus: 18 nTPM
  • hippocampal formation: 17 nTPM
  • amygdala: 16 nTPM
  • basal ganglia: 16 nTPM

Single-cell type

  • late primary spermatocytes: 287 nCPM
  • esophageal apical cells: 232 nCPM
  • oocytes: 180 nCPM
  • early primary spermatocytes: 163 nCPM
  • bergmann glia: 142 nCPM
  • oligodendrocytes: 132 nCPM

Immune cell

  • basophil: 12 nTPM
  • memory CD8 T-cell: 11 nTPM
  • eosinophil: 11 nTPM
  • plasmacytoid DC: 10 nTPM
  • naive CD8 T-cell: 9.7 nTPM
  • naive CD4 T-cell: 9.6 nTPM

Brain region

  • white matter: 29 nTPM
  • medulla oblongata: 20 nTPM
  • pons: 19 nTPM
  • basal ganglia: 19 nTPM
  • spinal cord: 19 nTPM
  • cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
gnomAD missense Z
0.62
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 20% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMC2 as an antibody target. Whether an autoantibody or antibody against EMC2 could matter depends on whether native EMC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EMC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EMC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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