Seroatlas · Human Serome Atlas

RPL9

Large ribosomal subunit protein uL6

Also known as: L9, RL9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32969
Gene
RPL9
Ensembl
ENSG00000163682
Chromosome
4
Canonical length
192 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Ribosomal proteins
Subcellular location
Nucleoli,Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>P32969|RPL9
     1  MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW
    61  WGNRKELATV RTICSHVQNM IKGVTLGFRY KMRSVYAHFP INVVIQENGS LVEIRNFLGE
   121  KYIRRVRMRP GVACSVSQAQ KDELILEGND IELVSNSAAL IQQATTVKNK DIRKFLDGIY
   181  VSEKGTVQQA DE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
3,758 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 3,758 nTPM
  • pancreas: 2,826 nTPM
  • bone marrow: 2,320 nTPM
  • epididymis: 2,196 nTPM
  • skin: 2,180 nTPM
  • breast: 2,155 nTPM

Single-cell type

  • esophageal suprabasal cells: 6,850 nCPM
  • extravillous trophoblasts: 6,511 nCPM
  • decidual stromal cells: 5,820 nCPM
  • ovarian stromal cells: 5,541 nCPM
  • esophageal basal cells: 5,486 nCPM
  • esophageal apical cells: 5,301 nCPM

Immune cell

  • total PBMC: 1,006 nTPM
  • naive CD4 T-cell: 876 nTPM
  • memory B-cell: 790 nTPM
  • MAIT T-cell: 715 nTPM
  • naive CD8 T-cell: 711 nTPM
  • naive B-cell: 684 nTPM

Brain region

  • hypothalamus: 296 nTPM
  • spinal cord: 155 nTPM
  • white matter: 130 nTPM
  • thalamus: 113 nTPM
  • basal ganglia: 106 nTPM
  • midbrain: 104 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.96
gnomAD missense Z
1.59
DepMap mean gene effect
-2.22
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein uL6-like
  • Large ribosomal subunit protein uL6, conserved site-2
  • Large ribosomal subunit protein uL6, alpha-beta domain
  • Large ribosomal subunit protein uL6-like, alpha-beta domain superfamily
  • Ribosomal protein L6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL9 as an antibody target. Whether an autoantibody or antibody against RPL9 could matter depends on whether native RPL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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