Seroatlas · Human Serome Atlas

MAPRE1

Microtubule-associated protein RP/EB family member 1

Also known as: EB1, MARE1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15691
Gene
MAPRE1
Ensembl
ENSG00000101367
Chromosome
20
Canonical length
268 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Centrosome,Basal body,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

268 residues, UniProt reviewed canonical sequence.

>Q15691|MAPRE1
     1  MAVNVYSTSV TSDNLSRHDM LAWINESLQL NLTKIEQLCS GAAYCQFMDM LFPGSIALKK
    61  VKFQAKLEHE YIQNFKILQA GFKRMGVDKI IPVDKLVKGK FQDNFEFVQW FKKFFDANYD
   121  GKDYDPVAAR QGQETAVAPS LVAPALNKPK KPLTSSSAAP QRPISTQRTA AAPKAGPGVV
   181  RKNPGVGNGD DEAAELMQQV NVLKLTVEDL EKERDFYFGK LRNIELICQE NEGENDPVLQ
   241  RIVDILYATD EGFVIPDEGG PQEEQEEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPRE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
182 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 182 nTPM
  • smooth muscle: 85 nTPM
  • thymus: 82 nTPM
  • urinary bladder: 78 nTPM
  • lymph node: 71 nTPM
  • blood vessel: 70 nTPM

Single-cell type

  • neutrophils: 304 nCPM
  • platelets: 288 nCPM
  • megakaryocytes: 278 nCPM
  • mast cells: 220 nCPM
  • syncytiotrophoblasts: 217 nCPM
  • extravillous trophoblasts: 174 nCPM

Immune cell

  • eosinophil: 263 nTPM
  • basophil: 258 nTPM
  • total PBMC: 186 nTPM
  • non-classical monocyte: 171 nTPM
  • intermediate monocyte: 151 nTPM
  • neutrophil: 140 nTPM

Brain region

  • midbrain: 88 nTPM
  • hypothalamus: 82 nTPM
  • medulla oblongata: 79 nTPM
  • spinal cord: 78 nTPM
  • thalamus: 77 nTPM
  • white matter: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
0.99
gnomAD missense Z
1.43
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPRE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPRE1 as an antibody target. Whether an autoantibody or antibody against MAPRE1 could matter depends on whether native MAPRE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPRE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAPRE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPRE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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