Seroatlas · Human Serome Atlas

KCNAB2

Voltage-gated potassium channel subunit beta-2

Also known as: AKR6A5, HKvbeta2.1, HKvbeta2.2, KCAB2_HUMAN, KCNA2B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13303
Gene
KCNAB2
Ensembl
ENSG00000069424
Chromosome
1
Canonical length
367 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Quaternary structure
Homotetramer

OverviewNCBI Gene

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q13303|KCNAB2
     1  MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS CLGLGTWVTF
    61  GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG NIIKKKGWRR SSLVITTKIF
   121  WGGKAETERG LSRKHIIEGL KASLERLQLE YVDVVFANRP DPNTPMEETV RAMTHVINQG
   181  MAMYWGTSRW SSMEIMEAYS VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA
   241  MTWSPLACGI VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG
   301  CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE IDSILGNKPY
   361  SKKDYRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNAB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
202 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 202 nTPM
  • hippocampal formation: 161 nTPM
  • amygdala: 128 nTPM
  • basal ganglia: 112 nTPM
  • bone marrow: 61 nTPM
  • spleen: 48 nTPM

Single-cell type

  • neutrophils: 239 nCPM
  • melanocytes: 202 nCPM
  • kupffer cells: 181 nCPM
  • neutrophil progenitors: 160 nCPM
  • monocytes: 159 nCPM
  • monocyte progenitors: 151 nCPM

Immune cell

  • total PBMC: 43 nTPM
  • classical monocyte: 34 nTPM
  • myeloid DC: 31 nTPM
  • gdT-cell: 30 nTPM
  • memory CD8 T-cell: 28 nTPM
  • intermediate monocyte: 27 nTPM

Brain region

  • cerebral cortex: 508 nTPM
  • hippocampal formation: 414 nTPM
  • white matter: 299 nTPM
  • pons: 285 nTPM
  • basal ganglia: 266 nTPM
  • amygdala: 265 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.39
gnomAD pLI
0.8
gnomAD missense Z
2.6
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNAB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNAB2 as an antibody target. Whether an autoantibody or antibody against KCNAB2 could matter depends on whether native KCNAB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNAB2 is annotated at the cell surface, where native KCNAB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNAB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNAB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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