Seroatlas · Human Serome Atlas

AGBL2

Cytosolic carboxypeptidase 2

Also known as: CBPC2_HUMAN, CCP2, FLJ23598

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5U5Z8
Gene
AGBL2
Ensembl
ENSG00000165923
Chromosome
11
Canonical length
902 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoli,Basal body,Cytosol,Flagellar centriole,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in protein side chain deglutamylation. Located in centriole and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

902 residues, UniProt reviewed canonical sequence.

>Q5U5Z8|AGBL2
     1  MFPALETHLK QTIPDPYEDF MYRHLQYYGY FKAQRGSLPN SATHQHVRKN NPQCLLNGSL
    61  GEKDDLIPDT LQKEKLLWPI SLSSAVHRQI EAINRDFHSC LGWMQWRGLS SLQPPPPRFK
   121  DSPASAFRVA GITDSHMLSL PHLRSRQLLY DELDEVNPRL REPQELFSIL STKRPLQAPR
   181  WPIECEVIKE NIHHIEWAPP QPEYFYQPKG NEKVPEIVGE KKGTVVYQLD SVPIEGSYFT
   241  SSRVGGKRGI VKELAVTLQG PEDNTLLFES RFESGNLQKA VRVDTYEYEL TLRTDLYTNK
   301  HTQWFYFRVQ NTRKDATYRF TIVNLLKPKS LYTVGMKPLL YSQLDANTRN IGWRREGNEI
   361  KYYKNNTDDG QQPFYCLTWT IQFPYDQDTC FFAHFYPYTY TDLQCYLLSV ANNPIQSQFC
   421  KLQTLCRSLA GNTVYLLTIT NPSQTPQEAA AKKAVVLSAR VHPGESNGSW VMKGFLDFIL
   481  SNSPDAQLLR DIFVFKVLPM LNPDGVIVGN YRCSLAGRDL NRHYKTILKE SFPCIWYTRN
   541  MIKRLLEERE VLLYCDFHGH SRKNNIFLYG CNNNNRKYWL HERVFPLMLC KNAPDKFSFH
   601  SCNFKVQKCK EGTGRVVMWR MGILNSYTME STFGGSTLGN KRDTHFTIED LKSLGYHVCD
   661  TLLDFCDPDQ MKFTQCLAEL KELLRQEIHK KFHELGQDVD LEGSWSDISL SDIESSTSGS
   721  DSSLSDGLPV HLANIADELT QKKKMFKKKK KKSLQTRKQR NEQYQKKNLM QKLKLTEDTS
   781  EKAGFASTLQ KQPTFFKNSE NSSFLPMKNE NPRLNETNLN RRDKDTPLDP SMATLILPKN
   841  KGRMQNKKPG FTVSCSPKRT INSSQEPAPG MKPNWPRSRY PATKRGCAAM AAYPSLHIYT
   901  YP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGBL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • testis: 11 nTPM
  • fallopian tube: 5.1 nTPM
  • liver: 2.7 nTPM
  • kidney: 1.9 nTPM
  • pituitary gland: 1.6 nTPM
  • choroid plexus: 1.5 nTPM

Single-cell type

  • ependymal cells: 117 nCPM
  • choroid plexus epithelial cells: 25 nCPM
  • late primary spermatocytes: 17 nCPM
  • respiratory ciliated cells: 15 nCPM
  • early spermatids: 15 nCPM
  • epididymal efferent duct ciliated cells: 14 nCPM

Immune cell

  • naive B-cell: 0.5 nTPM
  • T-reg: 0.5 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • gdT-cell: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM

Brain region

  • choroid plexus: 5.5 nTPM
  • midbrain: 3.6 nTPM
  • medulla oblongata: 2.5 nTPM
  • spinal cord: 2.2 nTPM
  • cerebellum: 1.7 nTPM
  • pons: 1.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AGBL2.

Disease | AutoantibodyPubMed

Conditions in which antibodies against AGBL2 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for AGBL2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

67 publications

Show 20 more of 67 total

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
1.17
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGBL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGBL2 as an antibody target. Whether an autoantibody or antibody against AGBL2 could matter depends on whether native AGBL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGBL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGBL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGBL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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