Seroatlas · Human Serome Atlas

STIM1

Stromal interaction molecule 1

Also known as: D11S4896E, GOK, STIM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13586
Gene
STIM1
Ensembl
ENSG00000167323
Chromosome
11
Canonical length
685 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homooligomer

OverviewNCBI Gene

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

685 residues, UniProt reviewed canonical sequence.

>Q13586|STIM1
     1  MDVCVRLALW LLWGLLLHQG QSLSHSHSEK ATGTSSGANS EESTAAEFCR IDKPLCHSED
    61  EKLSFEAVRN IHKLMDDDAN GDVDVEESDE FLREDLNYHD PTVKHSTFHG EDKLISVEDL
   121  WKAWKSSEVY NWTVDEVVQW LITYVELPQY EETFRKLQLS GHAMPRLAVT NTTMTGTVLK
   181  MTDRSHRQKL QLKALDTVLF GPPLLTRHNH LKDFMLVVSI VIGVGGCWFA YIQNRYSKEH
   241  MKKMMKDLEG LHRAEQSLHD LQERLHKAQE EHRTVEVEKV HLEKKLRDEI NLAKQEAQRL
   301  KELREGTENE RSRQKYAEEE LEQVREALRK AEKELESHSS WYAPEALQKW LQLTHEVEVQ
   361  YYNIKKQNAE KQLLVAKEGA EKIKKKRNTL FGTFHVAHSS SLDDVDHKIL TAKQALSEVT
   421  AALRERLHRW QQIEILCGFQ IVNNPGIHSL VAALNIDPSW MGSTRPNPAH FIMTDDVDDM
   481  DEEIVSPLSM QSPSLQSSVR QRLTEPQHGL GSQRDLTHSD SESSLHMSDR QRVAPKPPQM
   541  SRAADEALNA MTSNGSHRLI EGVHPGSLVE KLPDSPALAK KALLALNHGL DKAHSLMELS
   601  PSAPPGGSPH LDSSRSHSPS SPDPDTPSPV GDSRALQASR NTRIPHLAGK KAVAEEDNGS
   661  IGEETDSSPG RKKFPLKIFK KPLKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 105 nTPM
  • thymus: 63 nTPM
  • esophagus: 62 nTPM
  • salivary gland: 55 nTPM
  • tongue: 47 nTPM
  • thyroid gland: 44 nTPM

Single-cell type

  • neutrophil progenitors: 770 nCPM
  • neutrophils: 724 nCPM
  • thymic myoid cells: 621 nCPM
  • myonuclei: 526 nCPM
  • salivary acinar cells: 364 nCPM
  • thymocytes: 358 nCPM

Immune cell

  • non-classical monocyte: 25 nTPM
  • NK-cell: 21 nTPM
  • memory CD8 T-cell: 20 nTPM
  • eosinophil: 20 nTPM
  • gdT-cell: 18 nTPM
  • total PBMC: 16 nTPM

Brain region

  • cerebral cortex: 74 nTPM
  • amygdala: 71 nTPM
  • basal ganglia: 67 nTPM
  • choroid plexus: 63 nTPM
  • hypothalamus: 58 nTPM
  • thalamus: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about STIM1.

Disease | AllUniProt

Conditions STIM1 is implicated in, by any mechanism.

Disease | GeneticClinVar

37 pathogenic / likely-pathogenic of 909 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Combined immunodeficiency due to STIM1 deficiency
  • Stormorken syndrome
  • Myopathy with tubular aggregates
  • Myopathy, tubular aggregate, 1
  • Myopathy, autophagic vacuolar, infantile-onset

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.38
gnomAD pLI
0.78
gnomAD missense Z
2.12
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STIM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STIM1 as an antibody target. Whether an autoantibody or antibody against STIM1 could matter depends on whether native STIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STIM1 is annotated at the cell surface, where native STIM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STIM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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