Seroatlas · Human Serome Atlas

GAS2L3

GAS2-like protein 3

Also known as: GA2L3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XJ1
Gene: GAS2L3
Ensembl: ENSG00000139354
Chromosome: 12
Canonical length: 694 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables actin binding activity and microtubule binding activity. Involved in actin cytoskeleton organization and microtubule cytoskeleton organization. Located in actin cytoskeleton and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

694 residues, UniProt reviewed canonical sequence.

>Q86XJ1|GAS2L3
     1  MQPAIQVWFG EDLPLSPRSP LTPRHGPGLA NVCQYDEWIA VRHEATLLPM QEDLSIWLSG
    61  LLGIKVKAEK LLEELDNGVL LCQLIDVLQN MVKTCNSEES GNFPMRKVPC KKDAASGSFF
   121  ARDNTANFLH WCRDIGVDET YLFESEGLVL HKDPRQVYLC LLEIGRIVSR YGVEPPVLVK
   181  LEKEIELEET LLNTSGPEDS ISIPKSCCRH EELHEAVKHI AEDPPCSCSH RFSIEYLSEG
   241  RYRLGDKILF IRMLHGKHVM VRVGGGWDTL QGFLLKYDPC RILQFATLEQ KILAFQKGVS
   301  NESVPDSPAR TPQPPEMNPL SAVNMFQKQN SKPSVPVSIP KSKEKQGRPP GALVPASSLK
   361  GGNLGSMSVR SKLPNSPAAS SHPKLKSSKG ITKKPQAPSN NASSSLASLN PVGKNTSSPA
   421  LPRTAPCISE SPRKCISSPN TPKAKVIPAQ NSADLPESTL LPNKCSGKTQ PKYLKHNHIS
   481  SRDNAVSHLA AHSNSSSKCP KLPKANIPVR PKPSFQSSAK MTKTSSKTIA TGLGTQSQPS
   541  DGAPQAKPVP AQKLKSALNL NQPVSVSSVS PVKATQKSKD KNIVSATKKQ PQNKSAFQKT
   601  GPSSLKSPGR TPLSIVSLPQ SSTKTQTAPK SAQTVAKSQH STKGPPRSGK TPASIRKPPS
   661  SVKDADSGDK KPTAKKKEDD DHYFVMTGSK KPRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS2L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 5.3 nTPM
gallbladder: 4.5 nTPM
testis: 3.7 nTPM
rectum: 3.6 nTPM
skin: 3.6 nTPM
placenta: 3.3 nTPM

Single-cell type

schwann cells: 204 nCPM
macrophages: 104 nCPM
syncytiotrophoblasts: 102 nCPM
hofbauer cells: 78 nCPM
goblet cells: 73 nCPM
colonocytes: 68 nCPM

Immune cell

myeloid DC: 1.5 nTPM
intermediate monocyte: 1.3 nTPM
plasmacytoid DC: 0.4 nTPM
basophil: 0.2 nTPM
classical monocyte: 0.2 nTPM
neutrophil: 0.1 nTPM

Brain region

thalamus: 4.8 nTPM
cerebral cortex: 4.5 nTPM
white matter: 3.5 nTPM
choroid plexus: 3.4 nTPM
hippocampal formation: 3 nTPM
medulla oblongata: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GAS2L3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS2L3 as an antibody target. Whether an autoantibody or antibody against GAS2L3 could matter depends on whether native GAS2L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS2L3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAS2L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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