Seroatlas · Human Serome Atlas

MTUS2

Microtubule-associated tumor suppressor candidate 2

Also known as: CAZIP, ICIS, KIAA0774, MTUS2_HUMAN, TIP150

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JR59
Gene: MTUS2
Ensembl: ENSG00000132938
Chromosome: 13
Canonical length: 1369 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables microtubule binding activity and protein homodimerization activity. Located in centrosome; cytoplasmic microtubule; and intercellular bridge. Part of nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1369 residues, UniProt reviewed canonical sequence.

>Q5JR59|MTUS2
     1  MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE SKTCDLGDEI
    61  GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL SSTIQRELNE EHTVERGTDS
   121  LQTTRSIQGP SLSSWRNVMS EASLDVLAKR DAEIPRHVPK DKLAKTLDNE ELRRHSLERA
   181  SSSVAAVGSL TPQHPQPLSL DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS
   241  VRHPKPSTSE SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ
   301  LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG EAHPEATDAL
   361  GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS ASLGGADNQP TGKISPCAGE
   421  KLGERTSSSF SPGDSHVAFI PNNLTDSKPL DVIEEERRLG SGNKDSVMVL VFNPSVGENK
   481  TEVPEPLDPQ SGRSEARESK EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET
   541  TVNMTYQPTT PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP
   601  VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR NPQALGQVDA
   661  SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK PDLQKPRVFS SGLMVSGIKP
   721  PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS
   781  AKSRILIASQ RSSASAIHPP GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG
   841  YSRLPAAKLA AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK
   901  DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP AVSSPKRVAA
   961  STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR LKERCEQQTR QLGVAQGELK
  1021  RAICGFDALA VATQHFFRKN ESALVKEKEL SIELANIRDE VAFHTAKCEK LQKEKEELER
  1081  RFEDEVKRLG WQQQAELQEL EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS
  1141  HDAALLEMEN NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT
  1201  FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN QQIHEQEKKI
  1261  LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ LSEENANLQE YVEKETQEKK
  1321  RLSRTNEELL WKLQTGDPTS PIKLSPTSPV YRGSSSGPSS PARVSTTPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MTUS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 47 nTPM
blood vessel: 13 nTPM
ovary: 6.6 nTPM
pituitary gland: 5.8 nTPM
cerebellum: 5.1 nTPM
cerebral cortex: 4.9 nTPM

Single-cell type

cardiomyocytes: 1,358 nCPM
retinal bipolar cells: 911 nCPM
lactotrophs: 831 nCPM
choroid plexus epithelial cells: 599 nCPM
thyrotrophs: 598 nCPM
somatotrophs: 594 nCPM

Immune cell

eosinophil: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
myeloid DC: 0.2 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 41 nTPM
white matter: 25 nTPM
choroid plexus: 23 nTPM
thalamus: 21 nTPM
cerebellum: 21 nTPM
basal ganglia: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.8
gnomAD missense Z: 0.08
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MTUS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MTUS2 as an antibody target. Whether an autoantibody or antibody against MTUS2 could matter depends on whether native MTUS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MTUS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MTUS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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