BICD2

Protein identityUniProt · HPA

UniProt accession

Q8TD16

Gene

BICD2

Ensembl

ENSG00000185963

Chromosome

9

Canonical length

824 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

Subcellular location

Golgi apparatus,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

824 residues, UniProt reviewed canonical sequence.

>Q8TD16|BICD2
     1  MSAPSEEEEY ARLVMEAQPE WLRAEVKRLS HELAETTREK IQAAEYGLAV LEEKHQLKLQ
    61  FEELEVDYEA IRSEMEQLKE AFGQAHTNHK KVAADGESRE ESLIQESASK EQYYVRKVLE
   121  LQTELKQLRN VLTNTQSENE RLASVAQELK EINQNVEIQR GRLRDDIKEY KFREARLLQD
   181  YSELEEENIS LQKQVSVLRQ NQVEFEGLKH EIKRLEEETE YLNSQLEDAI RLKEISERQL
   241  EEALETLKTE REQKNSLRKE LSHYMSINDS FYTSHLHVSL DGLKFSDDAA EPNNDAEALV
   301  NGFEHGGLAK LPLDNKTSTP KKEGLAPPSP SLVSDLLSEL NISEIQKLKQ QLMQMEREKA
   361  GLLATLQDTQ KQLEHTRGSL SEQQEKVTRL TENLSALRRL QASKERQTAL DNEKDRDSHE
   421  DGDYYEVDIN GPEILACKYH VAVAEAGELR EQLKALRSTH EAREAQHAEE KGRYEAEGQA
   481  LTEKVSLLEK ASRQDRELLA RLEKELKKVS DVAGETQGSL SVAQDELVTF SEELANLYHH
   541  VCMCNNETPN RVMLDYYREG QGGAGRTSPG GRTSPEARGR RSPILLPKGL LAPEAGRADG
   601  GTGDSSPSPG SSLPSPLSDP RREPMNIYNL IAIIRDQIKH LQAAVDRTTE LSRQRIASQE
   661  LGPAVDKDKE ALMEEILKLK SLLSTKREQI TTLRTVLKAN KQTAEVALAN LKSKYENEKA
   721  MVTETMMKLR NELKALKEDA ATFSSLRAMF ATRCDEYITQ LDEMQRQLAA AEDEKKTLNS
   781  LLRMAIQQKL ALTQRLELLE LDHEQTRRGR AKAAPKTKPA TPSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BICD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

61 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BICD2.

Disease | AllUniProt

Conditions BICD2 is implicated in, by any mechanism.

• Spinal muscular atrophy, lower extremity-predominant 2A, childhood onset, autosomal dominant (SMALED2A) MIM:615290
• Spinal muscular atrophy, lower extremity-predominant, 2B, prenatal onset, autosomal dominant (SMALED2B) MIM:618291

Disease | GeneticClinVar

38 pathogenic / likely-pathogenic of 960 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures
• Spinal muscular atrophy, lower extremity-predominant, 2b, prenatal onset, autosomal dominant
• Inborn genetic diseases
• Neuronopathy, distal hereditary motor, autosomal dominant
• Spinal muscular atrophy

Disease | ImmuneIEDB

Conditions an epitope on BICD2 was assayed in.

• human immunodeficiency virus infectious disease T cell

ReferencesPubMed · IEDB

Publications for BICD2 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.31

gnomAD pLI

0.98

gnomAD missense Z

2.21

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• centrosome localization
• microtubule anchoring at microtubule organizing center
• microtubule-based movement
• minus-end-directed organelle transport along microtubule
• mRNA transport
• protein localization to Golgi apparatus
• protein transport
• regulation of microtubule cytoskeleton organization
• retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Molecular functions

• cytoskeletal anchor activity
• dynactin binding
• dynein complex binding
• dynein light intermediate chain binding
• small GTPase binding

Cellular components

• annulate lamellae
• centrosome
• cytoplasm
• cytoplasmic vesicle
• cytosol
• Golgi apparatus
• nuclear envelope
• nuclear pore
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Bicaudal-D protein
• Microtubule-associated protein Bicaudal-D

KeywordsUniProt

• Acetylation
• Coiled coil
• Cytoplasm
• Cytoskeleton
• Golgi apparatus
• mRNA transport
• Neurodegeneration
• Nuclear pore complex
• Nucleus
• Phosphoprotein
• Protein transport
• Translocation
• Transport

InteractionsUniProt · HPA

Protein binding partners of BICD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CPNE4
• DNAI1
• DYNC1H1
• DYNC1I2
• DYNLL1
• KIF1C
• NEK9
• RAB6A
• RANBP2
• DCTN2
• DCTN1
• KIF5A
• DYNC1I1
• MAPRE1