Seroatlas · Human Serome Atlas

AIM2

Interferon-inducible protein AIM2

Also known as: AIM2_HUMAN, PYHIN4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14862
Gene
AIM2
Ensembl
ENSG00000163568
Chromosome
1
Canonical length
343 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Mitochondria,Cytosol
Quaternary structure
Homooligomer

OverviewNCBI Gene

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>O14862|AIM2
     1  MESKYKEILL LTGLDNITDE ELDRFKFFLS DEFNIATGKL HTANRIQVAT LMIQNAGAVS
    61  AVMKTIRIFQ KLNYMLLAKR LQEEKEKVDK QYKSVTKPKP LSQAEMSPAA SAAIRNDVAK
   121  QRAAPKVSPH VKPEQKQMVA QQESIREGFQ KRCLPVMVLK AKKPFTFETQ EGKQEMFHAT
   181  VATEKEFFFV KVFNTLLKDK FIPKRIIIIA RYYRHSGFLE VNSASRVLDA ESDQKVNVPL
   241  NIIRKAGETP KINTLQTQPL GTIVNGLFVV QKVTEKKKNI LFDLSDNTGK MEVLGVRNED
   301  TMKCKEGDKV RLTFFTLSKN GEKLQLTSGV HSTIKVIKAK KKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 48 nTPM
  • tonsil: 47 nTPM
  • spleen: 25 nTPM
  • appendix: 21 nTPM
  • small intestine: 16 nTPM
  • urinary bladder: 13 nTPM

Single-cell type

  • corticotrophs: 345 nCPM
  • thyrotrophs: 296 nCPM
  • somatotrophs: 228 nCPM
  • lactotrophs: 201 nCPM
  • choroid plexus epithelial cells: 171 nCPM
  • b-cells: 137 nCPM

Immune cell

  • memory B-cell: 146 nTPM
  • naive B-cell: 65 nTPM
  • basophil: 23 nTPM
  • neutrophil: 17 nTPM
  • T-reg: 12 nTPM
  • non-classical monocyte: 8.5 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • medulla oblongata: 2.7 nTPM
  • pons: 2.3 nTPM
  • amygdala: 1.9 nTPM
  • cerebellum: 1.9 nTPM
  • midbrain: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AIM2.

Disease | ImmuneIEDB

Conditions an epitope on AIM2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.64
gnomAD pLI
0
gnomAD missense Z
0.6
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIM2 as an antibody target. Whether an autoantibody or antibody against AIM2 could matter depends on whether native AIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AIM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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