Seroatlas · Human Serome Atlas

CEP43

Centrosomal protein 43

Also known as: CEP43_HUMAN, FGFR1OP, FOP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95684
Gene
CEP43
Ensembl
ENSG00000213066
Chromosome
6
Canonical length
399 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Centriolar satellite,Centrosome,Basal body
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>O95684|CEP43
     1  MAATAAAVVA EEDTELRDLL VQTLENSGVL NRIKAELRAA VFLALEEQEK VENKTPLVNE
    61  SLKKFLNTKD GRLVASLVAE FLQFFNLDFT LAVFQPETST LQGLEGRENL ARDLGIIEAE
   121  GTVGGPLLLE VIRRCQQKEK GPTTGEGALD LSDVHSPPKS PEGKTSAQTT PSKIPRYKGQ
   181  GKKKTSGQKA GDKKANDEAN QSDTSVSLSE PKSKSSLHLL SHETKIGSFL SNRTLDGKDK
   241  AGLCPDEDDM EGDSFFDDPI PKPEKTYGLR KEPRKQAGSL ASLSDAPPLK SGLSSLAGAP
   301  SLKDSESKRG NTVLKDLKLI SDKIGSLGLG TGEDDDYVDD FNSTSHRSEK SEISIGEEIE
   361  EDLSVEIDDI NTSDKLDDLT QDLTVSQLSD VADYLEDVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • testis: 44 nTPM
  • liver: 26 nTPM
  • fallopian tube: 15 nTPM
  • thyroid gland: 14 nTPM
  • cerebellum: 13 nTPM
  • pituitary gland: 13 nTPM

Single-cell type

  • ependymal cells: 247 nCPM
  • late spermatids: 173 nCPM
  • early spermatids: 169 nCPM
  • proximal tubule cells: 110 nCPM
  • choroid plexus epithelial cells: 103 nCPM
  • brain inhibitory neurons: 89 nCPM

Immune cell

  • neutrophil: 31 nTPM
  • eosinophil: 17 nTPM
  • plasmacytoid DC: 9.8 nTPM
  • memory B-cell: 6.3 nTPM
  • classical monocyte: 5.1 nTPM
  • intermediate monocyte: 4.1 nTPM

Brain region

  • midbrain: 23 nTPM
  • cerebral cortex: 22 nTPM
  • cerebellum: 20 nTPM
  • choroid plexus: 20 nTPM
  • white matter: 20 nTPM
  • amygdala: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
DepMap mean gene effect
-0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP43 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP43 as an antibody target. Whether an autoantibody or antibody against CEP43 could matter depends on whether native CEP43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEP43. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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