Seroatlas · Human Serome Atlas

GAS2L2

GAS2-like protein 2

Also known as: GA2L2_HUMAN, GAR17

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NHY3
Gene
GAS2L2
Ensembl
ENSG00000270765
Chromosome
17
Canonical length
880 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene appears to crosslink microtubules and microfilaments and may be part of the cytoskeleton. This gene is mainly expressed in skeletal muscle. [provided by RefSeq, Jul 2011]

Canonical amino-acid sequenceUniProt

880 residues, UniProt reviewed canonical sequence.

>Q8NHY3|GAS2L2
     1  MSQPAGGRRK PRTLGPPVCS IRPFKSSEQY LEAMKEDLAE WLRDLYGLDI DAANFLQVLE
    61  TGLVLCQHAN VVTDAALAFL AEAPAQAQKI PMPRVGVSCN GAAQPGTFQA RDNVSNFIQW
   121  CRKEMGIQEV LMFETEDLVL RKNVKNVVLC LLELGRRAWR FGVAAPTLVQ LEEEIEEEVR
   181  RELALPPPDP SPPAPPRRQP CHFRNLDQMV QSLVSHCTCP VQFSMVKVSE GKYRVGDSNT
   241  LIFIRILRNH VMVRVGGGWD TLGHYLDKHD PCRCTSLSHK PGSFLKPPAP PVQHEVRVQD
   301  GPSQTQPTMT ISRSQSPPPP VDWKTYTSSD RRLRPPTPSS PRPRRERGAG TGASREMAPF
   361  LRCQERSLIP SWRQPTAGDS PPSPQSSSTQ KGRDPQCTSS GKREERYPPE LPRGRIPTSW
   421  VHEETDSWGT DAGNPTPQRL RAIEATTKGI SARGPSPLPR SFGPAECLGL RLPLRDEAKG
   481  AFFQFREPES VRSPTPVQGL TKIPIRLPPA RPPTPGRSFP GATSGSPRTE LGRDPIPLRA
   541  VTVDLAGSTH GDCSVEVRQE DQQLDIQVMA EARESWDLGL QEQEGRYTPL PLGGNKEQAI
   601  YCSLEEEILG NMKLLEVRSA CPQGTRSGVI PRSGVYIPRL AGQWPEPGGP YDKAIQELAQ
   661  GSPSLLKVDL EAWKAAPTGS PKPAVTPGPG SLKGKLGARQ SGPRTKASLS AKGTHMRKVP
   721  PQGGQDCSAS TVSASPEAPT PSPLDPNSDK AKACLSKGRR TLRKPKRVPS IYKLKLRPRI
   781  RPRRDHRPEK QPSRIPRPLA YVFLGPARQP PKDRLLRAVL GSKGGEASRV DGASVGEEEE
   841  EGKEEKEPAA PLESSPQPPE GLQPHWLNQA PLPPEEESWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS2L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 15 nTPM
  • choroid plexus: 8.5 nTPM
  • skeletal muscle: 2.5 nTPM
  • basal ganglia: 1.8 nTPM
  • lung: 1.8 nTPM
  • epididymis: 1.7 nTPM

Single-cell type

  • respiratory ciliated cells: 55 nCPM
  • fallopian tube ciliated cells: 55 nCPM
  • endometrial ciliated cells: 27 nCPM
  • epididymal efferent duct ciliated cells: 21 nCPM
  • ependymal cells: 15 nCPM
  • breast lactating cells: 6.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • midbrain: 4.9 nTPM
  • spinal cord: 3.8 nTPM
  • medulla oblongata: 3.4 nTPM
  • pons: 2.1 nTPM
  • basal ganglia: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GAS2L2.

Disease | AllUniProt

Conditions GAS2L2 is implicated in, by any mechanism.

  • Ciliary dyskinesia, primary, 41 (CILD41) MIM:618449

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 225 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0
gnomAD missense Z
-0.36
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GAS2L2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS2L2 as an antibody target. Whether an autoantibody or antibody against GAS2L2 could matter depends on whether native GAS2L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS2L2 is annotated at the cell surface, where native GAS2L2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GAS2L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAS2L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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