Seroatlas · Human Serome Atlas

RARRES1

Retinoic acid receptor responder protein 1

Also known as: LXNL, TIG1, TIG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49788
Gene
RARRES1
Ensembl
ENSG00000118849
Chromosome
3
Canonical length
294 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Golgi apparatus
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

294 residues, UniProt reviewed canonical sequence.

>P49788|RARRES1
     1  MQPRRQRLPA PWSGPRGPRP TAPLLALLLL LAPVAAPAGS GDPDDPGQPQ DAGVPRRLLQ
    61  QAARAALHFF NFRSGSPSAL RVLAEVQEGR AWINPKEGCK VHVVFSTERY NPESLLQEGE
   121  GRLGKCSARV FFKNQKPRPT INVTCTRLIE KKKRQQEDYL LYKQMKQLKN PLEIVSIPDN
   181  HGHIDPSLRL IWDLAFLGSS YVMWEMTTQV SHYYLAQLTS VRQWKTNDDT IDFDYTVLLH
   241  ELSTQEIIPC RIHLVWYPGK PLKVKYHCQE LQTPEEASGT EEGSAVVPTE LSNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RARRES1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
234 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 234 nTPM
  • fallopian tube: 173 nTPM
  • salivary gland: 173 nTPM
  • urinary bladder: 86 nTPM
  • heart muscle: 85 nTPM
  • prostate: 80 nTPM

Single-cell type

  • endometrial secretory cells: 5,678 nCPM
  • prostatic club cells: 3,434 nCPM
  • conjunctival goblet cells: 3,280 nCPM
  • submucosal glandular cells: 1,611 nCPM
  • salivary ionocytes: 1,392 nCPM
  • mesothelial cells: 1,281 nCPM

Immune cell

  • naive B-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 28 nTPM
  • cerebral cortex: 6.6 nTPM
  • hippocampal formation: 6.4 nTPM
  • cerebellum: 6.3 nTPM
  • white matter: 5.9 nTPM
  • basal ganglia: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.61
gnomAD pLI
0
gnomAD missense Z
0.82
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RARRES1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RARRES1 as an antibody target. Whether an autoantibody or antibody against RARRES1 could matter depends on whether native RARRES1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RARRES1 is annotated as secreted, so native RARRES1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RARRES1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RARRES1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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