Seroatlas · Human Serome Atlas

KNSTRN

Small kinetochore-associated protein

Also known as: C15orf23, FLJ14502, kinastrin, SKAP, SKAP_HUMAN, TRAF4AF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y448
Gene
KNSTRN
Ensembl
ENSG00000128944
Chromosome
15
Canonical length
316 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Mitotic spindle,Centriolar satellite

OverviewNCBI Gene

Enables microtubule plus-end binding activity and protein homodimerization activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and ruffle. Implicated in actinic keratosis and skin squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q9Y448|KNSTRN
     1  MAAPEAPPLD RVFRTTWLST ECDSHPLPPS YRKFLFETQA ADLAGGTTVA AGNLLNESEK
    61  DCGQDRRAPG VQPCRLVTMT SVVKTVYSLQ PPSALSGGQP ADTQTRATSK SLLPVRSKEV
   121  DVSKQLHSGG PENDVTKITK LRRENGQMKA TDTATRRNVR KGYKPLSKQK SEEELKDKNQ
   181  LLEAVNKQLH QKLTETQGEL KDLTQKVELL EKFRDNCLAI LESKGLDPAL GSETLASRQE
   241  STTDHMDSML LLETLQEELK LFNETAKKQM EELQALKVKL EMKEERVRFL EQQTLCNNQV
   301  NDLTTALKEM EQLLEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KNSTRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • testis: 59 nTPM
  • thyroid gland: 51 nTPM
  • thymus: 24 nTPM
  • tonsil: 15 nTPM
  • breast: 13 nTPM
  • bone marrow: 13 nTPM

Single-cell type

  • late spermatids: 940 nCPM
  • early spermatids: 405 nCPM
  • late primary spermatocytes: 261 nCPM
  • extravillous trophoblasts: 47 nCPM
  • early primary spermatocytes: 43 nCPM
  • monocyte progenitors: 35 nCPM

Immune cell

  • non-classical monocyte: 48 nTPM
  • intermediate monocyte: 24 nTPM
  • myeloid DC: 18 nTPM
  • classical monocyte: 18 nTPM
  • eosinophil: 17 nTPM
  • basophil: 13 nTPM

Brain region

  • cerebellum: 12 nTPM
  • white matter: 12 nTPM
  • cerebral cortex: 12 nTPM
  • pons: 9.7 nTPM
  • basal ganglia: 9.6 nTPM
  • hypothalamus: 9.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KNSTRN.

Disease | AllUniProt

Conditions KNSTRN is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 85 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.98
gnomAD pLI
0
gnomAD missense Z
-0.46
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Small kinetochore-associated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KNSTRN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KNSTRN as an antibody target. Whether an autoantibody or antibody against KNSTRN could matter depends on whether native KNSTRN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KNSTRN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KNSTRN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KNSTRN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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