Seroatlas · Human Serome Atlas

SLAIN2

SLAIN motif-containing protein 2

Also known as: FLJ21611, KIAA1458, SLAI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P270
Gene
SLAIN2
Ensembl
ENSG00000109171
Chromosome
4
Canonical length
581 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Cytosol

OverviewNCBI Gene

Involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Located in centrosome; cytosol; and microtubule plus-end. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>Q9P270|SLAIN2
     1  MEDVNSNVNA DQEVRKLQEL VKKLEKQNEQ LRSRSGAVQG AGSLGPGSPV RAGASIPSSG
    61  AASPRGFPLG LSAKSGGGPG SGPRRTSSEE LRDATSLLAA GEGGLLDEVE PLRPDELERL
   121  SGWEEEEESW LYSSPKKKLT PMQKSVSPLV WCRQVLDYPS PDVECAKKSL IHKLDQTMSA
   181  LKRQNLYNNP FNSMSYTSPY SPNASSPYSS GFNSPSSTPV RPPIVKQLIL PGNSGNLKSS
   241  DRNPPLSPQS SIDSELSASE LDEDSIGSNY KLNDVTDVQI LARMQEESLR QEYAATTSRR
   301  SSGSSCNSTR RGTFSDQELD AQSLDDEDDN MHHAVYPAVN RFSPSPRNSP RPSPKQSPRN
   361  SPRSRSPARG IEYSRVSPQP MISRLQQPRL SLQGHPTDLQ TSNVKNEEKL RRSLPNLSRT
   421  SNTQVDSVKS SRSDSNFQVP NGGIPRMQPQ ASAIPSPGKF RSPAAPSPLA LRQPVKAFSN
   481  HGSGSPGSQE ITQLTQTTSS PGPPMVQSTV SANPPSNINS ATLTRPAGTT AMRSGLPRPS
   541  APSAGGIPVP RSKLAQPVRR SLPAPKTYGS MKDDSWKDGC Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLAIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 92 nTPM
  • skeletal muscle: 68 nTPM
  • testis: 39 nTPM
  • heart muscle: 38 nTPM
  • esophagus: 37 nTPM
  • blood vessel: 36 nTPM

Single-cell type

  • late spermatids: 564 nCPM
  • fallopian tube ciliated cells: 225 nCPM
  • megakaryocytes: 223 nCPM
  • esophageal apical cells: 207 nCPM
  • rod photoreceptor cells: 195 nCPM
  • endometrial stromal cells: 185 nCPM

Immune cell

  • memory CD8 T-cell: 9.9 nTPM
  • basophil: 9.5 nTPM
  • NK-cell: 8.8 nTPM
  • memory CD4 T-cell: 8.3 nTPM
  • eosinophil: 7.7 nTPM
  • naive B-cell: 7.6 nTPM

Brain region

  • choroid plexus: 30 nTPM
  • cerebellum: 30 nTPM
  • cerebral cortex: 27 nTPM
  • thalamus: 25 nTPM
  • white matter: 24 nTPM
  • midbrain: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.79
gnomAD missense Z
0.72
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLAIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLAIN2 as an antibody target. Whether an autoantibody or antibody against SLAIN2 could matter depends on whether native SLAIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLAIN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLAIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLAIN2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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