Seroatlas · Human Serome Atlas

GAS2L1

GAS2-like protein 1

Also known as: GA2L1_HUMAN, GAR22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99501
Gene: GAS2L1
Ensembl: ENSG00000185340
Chromosome: 22
Canonical length: 681 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. This protein localizes to the proximal end of mature centrioles and links centrosomes to both microtubules and actin. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2018]

Canonical amino-acid sequenceUniProt

681 residues, UniProt reviewed canonical sequence.

>Q99501|GAS2L1
     1  MADPVAGIAG SAAKSVRPFR SSEAYVEAMK EDLAEWLNAL YGLGLPGGGD GFLTGLATGT
    61  TLCQHANAVT EAARALAAAR PARGVAFQAH SVVPGSFMAR DNVATFIGWC RVELGVPEVL
   121  MFETEDLVLR KNEKSVVLCL LEVARRGARL GLLAPRLVQF EQEIERELRA APPAPNAPAA
   181  GEDTTETAPA PGTPARGPRM TPSDLRNLDE LVREILGRCT CPDQFPMIKV SEGKYRVGDS
   241  SLLIFVRVLR SHVMVRVGGG WDTLEHYLDK HDPCRCSSTA HRPPQPRVCT FSPQRVSPTT
   301  SPRPASPVPG SERRGSRPEM TPVSLRSTKE GPETPPRPRD QLPPHPRSRR YSGDSDSSAS
   361  SAQSGPLGTR SDDTGTGPRR ERPSRRLTTG TPASPRRPPA LRSQSRDRLD RGRPRGAPGG
   421  RGAQLSVPSP ARRARSQSRE EQAVLLVRRD RDGQHSWVPR GRGSGGSGRS TPQTPRARSP
   481  AAPRLSRVSS PSPELGTTPA SIFRTPLQLD PQQEQQLFRR LEEEFLANAR ALEAVASVTP
   541  TGPVPDPARA PDPPAPDSAY CSSSSSSSSL SVLGGKCGQP GDSGRTANGL PGPRSQALSS
   601  SSDEGSPCPG MGGPLDAPGS PLACTEPSRT WARGRMDTQP DRKPSRIPTP RGPRRPSGPA
   661  ELGTWHALHS VTPRAEPDSW M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS2L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 55 nTPM
skin: 50 nTPM
testis: 50 nTPM
amygdala: 45 nTPM
basal ganglia: 45 nTPM
hippocampal formation: 41 nTPM

Single-cell type

platelets: 1,049 nCPM
megakaryocytes: 179 nCPM
late spermatids: 156 nCPM
epididymal principal cells: 76 nCPM
sertoli cells: 57 nCPM
esophageal basal cells: 50 nCPM

Immune cell

eosinophil: 0.9 nTPM
classical monocyte: 0.5 nTPM
non-classical monocyte: 0.4 nTPM
myeloid DC: 0.3 nTPM
total PBMC: 0.2 nTPM
neutrophil: 0.1 nTPM

Brain region

medulla oblongata: 79 nTPM
thalamus: 75 nTPM
cerebral cortex: 73 nTPM
amygdala: 72 nTPM
hippocampal formation: 69 nTPM
midbrain: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.83
gnomAD missense Z: 1.33
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GAS2L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAPRE1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS2L1 as an antibody target. Whether an autoantibody or antibody against GAS2L1 could matter depends on whether native GAS2L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS2L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAS2L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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