Seroatlas · Human Serome Atlas

SORBS3

Vinexin

Also known as: SCAM-1, SH3D4, VINEX_HUMAN, vinexin

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60504
Gene
SORBS3
Ensembl
ENSG00000120896
Chromosome
8
Canonical length
671 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

671 residues, UniProt reviewed canonical sequence.

>O60504|SORBS3
     1  MQGPPRSLRA GLSLDDFIPG HLQSHIGSSS RGTRVPVIRN GGSNTLNFQF HDPAPRTVCN
    61  GGYTPRRDAS QHPDPAWYQT WPGPGSKPSA STKIPASQHT QNWSATWTKD SKRRDKRWVK
   121  YEGIGPVDES GMPIAPRSSV DRPRDWYRRM FQQIHRKMPD LQLDWTFEEP PRDPRHLGAQ
   181  QRPAHRPGPA TSSSGRSWDH SEELPRSTFN YRPGAFSTVL QPSNQVLRRR EKVDNVWTEE
   241  SWNQFLQELE TGQRPKKPLV DDPGEKPSQP IEVLLERELA ELSAELDKDL RAIETRLPSP
   301  KSSPAPRRAP EQRPPAGPAS AWSSSYPHAP YLGSARSLSP HKMADGGSPF LGRRDFVYPS
   361  STRDPSASNG GGSPARREEK KRKAARLKFD FQAQSPKELT LQKGDIVYIH KEVDKNWLEG
   421  EHHGRLGIFP ANYVEVLPAD EIPKPIKPPT YQVLEYGEAV AQYTFKGDLE VELSFRKGEH
   481  ICLIRKVNEN WYEGRITGTG RQGIFPASYV QVSREPRLRL CDDGPQLPTS PRLTAAARSA
   541  RHPSSPSALR SPADPIDLGG QTSPRRTGFS FPTQEPRPQT QNLGTPGPAL SHSRGPSHPL
   601  DLGTSSPNTS QIHWTPYRAM YQYRPQNEDE LELREGDRVD VMQQCDDGWF VGVSRRTQKF
   661  GTFPGNYVAP V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SORBS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
240 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 240 nTPM
  • adipose tissue: 166 nTPM
  • cervix: 129 nTPM
  • vagina: 128 nTPM
  • breast: 124 nTPM
  • testis: 122 nTPM

Single-cell type

  • late spermatids: 931 nCPM
  • early spermatids: 219 nCPM
  • vascular smooth muscle cells: 153 nCPM
  • pericytes: 141 nCPM
  • hepatic stellate cells: 116 nCPM
  • leydig cells: 93 nCPM

Immune cell

  • MAIT T-cell: 23 nTPM
  • memory CD8 T-cell: 13 nTPM
  • memory CD4 T-cell: 13 nTPM
  • naive CD4 T-cell: 13 nTPM
  • gdT-cell: 12 nTPM
  • myeloid DC: 8.2 nTPM

Brain region

  • medulla oblongata: 128 nTPM
  • cerebellum: 88 nTPM
  • pons: 84 nTPM
  • thalamus: 84 nTPM
  • cerebral cortex: 83 nTPM
  • spinal cord: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0
gnomAD missense Z
-0.92
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SORBS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SORBS3 as an antibody target. Whether an autoantibody or antibody against SORBS3 could matter depends on whether native SORBS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SORBS3 is annotated at the cell surface, where native SORBS3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SORBS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SORBS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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