Seroatlas · Human Serome Atlas

MACC1

Metastasis-associated in colon cancer protein 1

Also known as: 7A5, MACC1_HUMAN, SH3BP4L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZN28
Gene
MACC1
Ensembl
ENSG00000183742
Chromosome
7
Canonical length
852 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]

Canonical amino-acid sequenceUniProt

852 residues, UniProt reviewed canonical sequence.

>Q6ZN28|MACC1
     1  MLITERKHFR SGRIAQSMSE ANLIDMEAGK LSKSCNITEC QDPDLLHNWP DAFTLRGNNA
    61  SKVANPFWNQ LSASNPFLDD ITQLRNNRKR NNISILKEDP FLFCREIENG NSFDSSGDEL
   121  DVHQLLRQTS SRNSGRSKSV SELLDILDDT AHAHQSIHNS DQILLHDLEW LKNDREAYKM
   181  AWLSQRQLAR SCLDLNTISQ SPGWAQTQLA EVTIACKVNH QGGSVQLPES DITVHVPQGH
   241  VAVGEFQEVS LRAFLDPPHM LNHDLSCTVS PLLEIMLGNL NTMEALLLEM KIGAEVRKDP
   301  FSQVMTEMVC LHSLGKEGPF KVLSNCYIYK DTIQVKLIDL SQVMYLVVAA QAKALPSPAA
   361  TIWDYIHKTT SIGIYGPKYI HPSFTVVLTV CGHNYMPGQL TISDIKKGGK NISPVVFQLW
   421  GKQSFLLDKP QDLSISIFSC DPDFEVKTEG ERKEIKQKQL EAGEVVHQQF LFSLVEHREM
   481  HLFDFCVQVE PPNGEPVAQF SITTPDPTPN LKRLSNLPGY LQKKEEIKSA PLSPKILVKY
   541  PTFQDKTLNF SNYGVTLKAV LRQSKIDYFL EYFKGDTIAL LGEGKVKAIG QSKVKEWYVG
   601  VLRGKIGLVH CKNVKVISKE QVMFMSDSVF TTRNLLEQIV LPLKKLTYIY SVVLTLVSEK
   661  VYDWKVLADV LGYSHLSLED FDQIQADKES EKVSYVIKKL KEDCHTERNT RKFLYELIVA
   721  LLKMDCQELV ARLIQEAAVL TSAVKLGKGW RELAEKLVRL TKQQMEAYEI PHRGNTGDVA
   781  VEMMWKPAYD FLYTWSAHYG NNYRDVLQDL QSALDRMKNP VTKHWRELTG VLILVNSLEV
   841  LRVTAFSTSE EV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MACC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 11 nTPM
  • duodenum: 9.2 nTPM
  • esophagus: 8.2 nTPM
  • kidney: 6.2 nTPM
  • salivary gland: 5.3 nTPM
  • lung: 5.1 nTPM

Single-cell type

  • endometrial secretory cells: 1,366 nCPM
  • endometrial luminal cells: 741 nCPM
  • urothelial cells: 709 nCPM
  • endometrial ciliated cells: 672 nCPM
  • endometrial glandular cells: 664 nCPM
  • epididymal clear cells: 527 nCPM

Immune cell

  • memory B-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM
  • basophil: 0.2 nTPM
  • neutrophil: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • pons: 9.8 nTPM
  • cerebral cortex: 9.6 nTPM
  • amygdala: 9.5 nTPM
  • white matter: 9.5 nTPM
  • medulla oblongata: 9.2 nTPM
  • cerebellum: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
-1.29
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MACC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MACC1 as an antibody target. Whether an autoantibody or antibody against MACC1 could matter depends on whether native MACC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MACC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MACC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MACC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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