Seroatlas · Human Serome Atlas

ARHGAP9

Rho GTPase-activating protein 9

Also known as: 10C, MGC1295, RHG09_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRR9
Gene: ARHGAP9
Ensembl: ENSG00000123329
Chromosome: 12
Canonical length: 750 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

750 residues, UniProt reviewed canonical sequence.

>Q9BRR9|ARHGAP9
     1  MLSSRWWPSS WGILGLGPRS PPRGSQLCAL YAFTYTGADG QQVSLAEGDR FLLLRKTNSD
    61  WWLARRLEAP STSRPIFVPA AYMIEESIPS QSPTTVIPGQ LLWTPGPKLF HGSLEELSQA
   121  LPSRAQASSE QPPPLPRKMC RSVSTDNLSP SLLKPFQEGP SGRSLSQEDL PSEASASTAG
   181  PQPLMSEPPV YCNLVDLRRC PRSPPPGPAC PLLQRLDAWE QHLDPNSGRC FYINSLTGCK
   241  SWKPPRRSRS ETNPGSMEGT QTLKRNNDVL QPQAKGFRSD TGTPEPLDPQ GSLSLSQRTS
   301  QLDPPALQAP RPLPQLLDDP HEVEKSGLLN MTKIAQGGRK LRKNWGPSWV VLTGNSLVFY
   361  REPPPTAPSS GWGPAGSRPE SSVDLRGAAL AHGRHLSSRR NVLHIRTIPG HEFLLQSDHE
   421  TELRAWHRAL RTVIERLVRW VEARREAPTG RDQGSGDREN PLELRLSGSG PAELSAGEDE
   481  EEESELVSKP LLRLSSRRSS IRGPEGTEQN RVRNKLKRLI AKRPPLQSLQ ERGLLRDQVF
   541  GCQLESLCQR EGDTVPSFLR LCIAAVDKRG LDVDGIYRVS GNLAVVQKLR FLVDRERAVT
   601  SDGRYVFPEQ PGQEGRLDLD STEWDDIHVV TGALKLFLRE LPQPLVPPLL LPHFRAALAL
   661  SESEQCLSQI QELIGSMPKP NHDTLRYLLE HLCRVIAHSD KNRMTPHNLG IVFGPTLFRP
   721  EQETSDPAAH ALYPGQLVQL MLTNFTSLFP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 113 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 113 nTPM
spleen: 97 nTPM
tonsil: 57 nTPM
lymph node: 53 nTPM
small intestine: 35 nTPM
thymus: 33 nTPM

Single-cell type

neutrophils: 429 nCPM
late primary spermatocytes: 204 nCPM
nk-cells: 147 nCPM
neutrophil progenitors: 142 nCPM
pdcs: 107 nCPM
innate lymphoid cells: 79 nCPM

Immune cell

neutrophil: 393 nTPM
eosinophil: 245 nTPM
plasmacytoid DC: 98 nTPM
intermediate monocyte: 90 nTPM
classical monocyte: 87 nTPM
myeloid DC: 72 nTPM

Brain region

pons: 15 nTPM
cerebral cortex: 14 nTPM
cerebellum: 14 nTPM
medulla oblongata: 11 nTPM
white matter: 11 nTPM
thalamus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Rho GTPase-activating protein domain
WW domain
SH3 domain
Pleckstrin homology domain
Rho GTPase activation protein
PH-like domain superfamily
WW domain superfamily
SH3-like domain superfamily
Rho GTPase-activating protein
SH3 domain
PH domain
RhoGAP domain
Rho GTPase-activating protein 9, SH3 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP9 as an antibody target. Whether an autoantibody or antibody against ARHGAP9 could matter depends on whether native ARHGAP9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP9 is annotated at the cell surface, where native ARHGAP9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGAP9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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