Seroatlas · Human Serome Atlas

SH3RF2

E3 ubiquitin-protein ligase SH3RF2

Also known as: FLJ23654, Hepp1, POSHER, PPP1R39, RNF158, SH3R2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TEC5
Gene: SH3RF2
Ensembl: ENSG00000156463
Chromosome: 5
Canonical length: 729 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

729 residues, UniProt reviewed canonical sequence.

>Q8TEC5|SH3RF2
     1  MDDLTLLDLL ECPVCFEKLD VTAKVLPCQH TFCKPCLQRV FKAHKELRCP ECRTPVFSNI
    61  EALPANLLLV RLLDGVRSGQ SSGRGGSFRR PGTMTLQDGR KSRTNPRRLQ ASPFRLVPNV
   121  RIHMDGVPRA KALCNYRGQN PGDLRFNKGD IILLRRQLDE NWYQGEINGI SGNFPASSVE
   181  VIKQLPQPPP LCRALYNFDL RGKDKSENQD CLTFLKDDII TVISRVDENW AEGKLGDKVG
   241  IFPILFVEPN LTARHLLEKN KGRQSSRTKN LSLVSSSSRG NTSTLRRGPG SRRKVPGQFS
   301  ITTALNTLNR MVHSPSGRHM VEISTPVLIS SSNPSVITQP MEKADVPSSC VGQVSTYHPA
   361  PVSPGHSTAV VSLPGSQQHL SANMFVALHS YSAHGPDELD LQKGEGVRVL GKCQDGWLRG
   421  VSLVTGRVGI FPNNYVIPIF RKTSSFPDSR SPGLYTTWTL STSSVSSQGS ISEGDPRQSR
   481  PFKSVFVPTA IVNPVRSTAG PGTLGQGSLR KGRSSMRKNG SLQRPLQSGI PTLVVGSLRR
   541  SPTMVLRPQQ FQFYQPQGIP SSPSAVVVEM GSKPALTGEP ALTCISRGSE AWIHSAASSL
   601  IMEDKEIPIK SEPLPKPPAS APPSILVKPE NSRNGIEKQV KTVRFQNYSP PPTKHYTSHP
   661  TSGKPEQPAT LKASQPEAAS LGPEMTVLFA HRSGCHSGQQ TDLRRKSALG KATTLVSTAS
   721  GTQTVFPSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3RF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 55 nTPM
skin: 54 nTPM
skeletal muscle: 40 nTPM
esophagus: 32 nTPM
vagina: 20 nTPM
stomach: 19 nTPM

Single-cell type

late spermatids: 13,188 nCPM
early spermatids: 1,910 nCPM
cardiomyocytes: 1,738 nCPM
basal keratinocytes: 576 nCPM
suprabasal keratinocytes: 535 nCPM
alveolar cells type 1: 447 nCPM

Immune cell

gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
basophil: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

basal ganglia: 14 nTPM
cerebral cortex: 10 nTPM
thalamus: 5 nTPM
amygdala: 2.7 nTPM
white matter: 2.2 nTPM
hypothalamus: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH3 domain
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type
Zinc finger, RING-type, conserved site
SH3-like domain superfamily
Endophilin/SH3RF
SH3 domain
Variant SH3 domain
Ring finger domain
Variant SH3 domain
E3 ubiquitin-protein ligase SH3RF2, RING finger, HC subclass
E3 ubiquitin-protein ligase SH3RF2, first SH3 domain
E3 ubiquitin-protein ligase SH3RF2, second SH3 domain
SH3RF2, third SH3 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH3RF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3RF2 as an antibody target. Whether an autoantibody or antibody against SH3RF2 could matter depends on whether native SH3RF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3RF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3RF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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