Seroatlas · Human Serome Atlas

SAMSN1

SAM domain-containing protein SAMSN-1

Also known as: HACS1, NASH1, SAMN1_HUMAN, SASH2, SH3D6B, SLy2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NSI8
Gene: SAMSN1
Ensembl: ENSG00000155307
Chromosome: 21
Canonical length: 373 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>Q9NSI8|SAMSN1
     1  MLKRKPSNVS EKEKHQKPKR SSSFGNFDRF RNNSLSKPDD STEAHEGDPT NGSGEQSKTS
    61  NNGGGLGKKM RAISWTMKKK VGKKYIKALS EEKDEEDGEN AHPYRNSDPV IGTHTEKVSL
   121  KASDSMDSLY SGQSSSSGIT SCSDGTSNRD SFRLDDDGPY SGPFCGRARV HTDFTPSPYD
   181  TDSLKIKKGD IIDIICKTPM GMWTGMLNNK VGNFKFIYVD VISEEEAAPK KIKANRRSNS
   241  KKSKTLQEFL ERIHLQEYTS TLLLNGYETL EDLKDIKESH LIELNIENPD DRRRLLSAAE
   301  NFLEEEIIQE QENEPEPLSL SSDISLNKSQ LDDCPRDSGC YISSGNSDNG KEDLESENLS
   361  DMVHKIIITE PSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMSN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 182 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 182 nTPM
appendix: 76 nTPM
tonsil: 38 nTPM
urinary bladder: 37 nTPM
lymph node: 33 nTPM
spleen: 30 nTPM

Single-cell type

neutrophils: 14,700 nCPM
monocytes: 2,677 nCPM
neutrophil progenitors: 1,993 nCPM
mast cells: 1,616 nCPM
t-cells: 891 nCPM
monocyte progenitors: 811 nCPM

Immune cell

basophil: 315 nTPM
eosinophil: 235 nTPM
non-classical monocyte: 83 nTPM
T-reg: 60 nTPM
intermediate monocyte: 52 nTPM
neutrophil: 50 nTPM

Brain region

white matter: 17 nTPM
medulla oblongata: 11 nTPM
pons: 9.1 nTPM
spinal cord: 9 nTPM
cerebral cortex: 8.5 nTPM
thalamus: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAMSN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMSN1 as an antibody target. Whether an autoantibody or antibody against SAMSN1 could matter depends on whether native SAMSN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMSN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMSN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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