Seroatlas · Human Serome Atlas

MIA

Melanoma-derived growth regulatory protein

Also known as: CD-RAP, MIA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16674
Gene: MIA
Ensembl: ENSG00000261857
Chromosome: 19
Canonical length: 131 aa
Protein class: Cancer-related genes, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable growth factor activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within cell-matrix adhesion. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>Q16674|MIA
     1  MARSLVCLGV IILLSAFSGP GVRGGPMPKL ADRKLCADQE CSHPISMAVA LQDYMAPDCR
    61  FLTIHRGQVV YVFSKLKGRG RLFWGGSVQG DYYGDLAARL GYFPSSIVRE DQTLKPGKVD
   121  VKTDKWDFYC Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 74 nTPM
stomach: 62 nTPM
breast: 54 nTPM
salivary gland: 41 nTPM
colon: 18 nTPM
blood vessel: 11 nTPM

Single-cell type

breast myoepithelial cells: 163 nCPM
mucous neck cells: 149 nCPM
breast secretory cells: 139 nCPM
melanocytes: 110 nCPM
gastric chief cells: 92 nCPM
submucosal glandular cells: 91 nCPM

Immune cell

neutrophil: 2.7 nTPM
basophil: 0.6 nTPM
eosinophil: 0.4 nTPM
memory B-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
gdT-cell: 0.1 nTPM

Brain region

white matter: 12 nTPM
basal ganglia: 8.6 nTPM
thalamus: 8.3 nTPM
cerebellum: 8 nTPM
pons: 7.9 nTPM
cerebral cortex: 7.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MIA.

Disease | ImmuneIEDB

Conditions an epitope on MIA was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: 0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

SH3 domain
SH3-like domain superfamily
Variant SH3 domain
Melanoma-derived growth regulatory protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIA as an antibody target. Whether an autoantibody or antibody against MIA could matter depends on whether native MIA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIA is annotated as secreted, so native MIA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label MIA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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