Seroatlas · Human Serome Atlas

OSTF1

Osteoclast-stimulating factor 1

Also known as: bA235O14.1, OSF, OSTF1_HUMAN, SH3P2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92882
Gene: OSTF1
Ensembl: ENSG00000134996
Chromosome: 9
Canonical length: 214 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q92882|OSTF1
     1  MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTNWW KGTSKGRTGL
    61  IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN GLDKAGSTAL YWACHGGHKD
   121  IVEMLFTQPN IELNQQNKLG DTALHAAAWK GYADIVQLLL AKGARTDLRN IEKKLAFDMA
   181  TNAACASLLK KKQGTDAVRT LSNAEDYLDD EDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSTF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

esophagus: 100 nTPM
spleen: 82 nTPM
tonsil: 80 nTPM
lymph node: 70 nTPM
parathyroid gland: 68 nTPM
placenta: 66 nTPM

Single-cell type

esophageal apical cells: 1,098 nCPM
neutrophils: 714 nCPM
hofbauer cells: 394 nCPM
extravillous trophoblasts: 375 nCPM
neutrophil progenitors: 358 nCPM
esophageal suprabasal cells: 318 nCPM

Immune cell

neutrophil: 497 nTPM
eosinophil: 466 nTPM
basophil: 361 nTPM
total PBMC: 283 nTPM
non-classical monocyte: 258 nTPM
intermediate monocyte: 199 nTPM

Brain region

basal ganglia: 38 nTPM
white matter: 38 nTPM
hypothalamus: 36 nTPM
pons: 35 nTPM
cerebral cortex: 35 nTPM
midbrain: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SH3 domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OSTF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSTF1 as an antibody target. Whether an autoantibody or antibody against OSTF1 could matter depends on whether native OSTF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSTF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OSTF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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