Seroatlas · Human Serome Atlas

PTK6

Protein-tyrosine kinase 6

Also known as: BRK, PTK6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13882
Gene
PTK6
Ensembl
ENSG00000101213
Chromosome
20
Canonical length
451 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>Q13882|PTK6
     1  MVSRDQAHLG PKYVGLWDFK SRTDEELSFR AGDVFHVARK EEQWWWATLL DEAGGAVAQG
    61  YVPHNYLAER ETVESEPWFF GCISRSEAVR RLQAEGNATG AFLIRVSEKP SADYVLSVRD
   121  TQAVRHYKIW RRAGGRLHLN EAVSFLSLPE LVNYHRAQSL SHGLRLAAPC RKHEPEPLPH
   181  WDDWERPREE FTLCRKLGSG YFGEVFEGLW KDRVQVAIKV ISRDNLLHQQ MLQSEIQAMK
   241  KLRHKHILAL YAVVSVGDPV YIITELMAKG SLLELLRDSD EKVLPVSELL DIAWQVAEGM
   301  CYLESQNYIH RDLAARNILV GENTLCKVGD FGLARLIKED VYLSHDHNIP YKWTAPEALS
   361  RGHYSTKSDV WSFGILLHEM FSRGQVPYPG MSNHEAFLRV DAGYRMPCPL ECPPSVHKLM
   421  LTCWCRDPEQ RPCFKALRER LSSFTSYENP T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 104 nTPM
  • skin: 51 nTPM
  • vagina: 41 nTPM
  • cervix: 34 nTPM
  • duodenum: 27 nTPM
  • stomach: 25 nTPM

Single-cell type

  • esophageal apical cells: 774 nCPM
  • esophageal suprabasal cells: 187 nCPM
  • colonocytes: 137 nCPM
  • enterocytes: 118 nCPM
  • foveolar cells: 95 nCPM
  • suprabasal keratinocytes: 78 nCPM

Immune cell

  • myeloid DC: 1.3 nTPM
  • classical monocyte: 0.7 nTPM
  • intermediate monocyte: 0.5 nTPM
  • MAIT T-cell: 0.5 nTPM
  • basophil: 0.4 nTPM
  • non-classical monocyte: 0.4 nTPM

Brain region

  • white matter: 14 nTPM
  • cerebellum: 9.7 nTPM
  • cerebral cortex: 8.6 nTPM
  • basal ganglia: 7.5 nTPM
  • pons: 7.5 nTPM
  • medulla oblongata: 7.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTK6.

Disease | ImmuneIEDB

Conditions an epitope on PTK6 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
0.39
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTK6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTK6 as an antibody target. Whether an autoantibody or antibody against PTK6 could matter depends on whether native PTK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTK6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTK6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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