Seroatlas · Human Serome Atlas

WBP11

WW domain-binding protein 11

Also known as: BUG13, NPWBP, PPP1R165, SIPP1, WBP11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2W2
Gene
WBP11
Ensembl
ENSG00000084463
Chromosome
12
Canonical length
641 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol,Acrosome,Principal piece,End piece

OverviewNCBI Gene

This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

641 residues, UniProt reviewed canonical sequence.

>Q9Y2W2|WBP11
     1  MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP KQIIRDMEKL
    61  DEMEFNPVQQ PQLNEKVLKD KRKKLRETFE RILRLYEKEN PDIYKELRKL EVEYEQKRAQ
   121  LSQYFDAVKN AQHVEVESIP LPDMPHAPSN ILIQDIPLPG AQPPSILKKT SAYGPPTRAV
   181  SILPLLGHGV PRLPPGRKPP GPPPGPPPPQ VVQMYGRKVG FALDLPPRRR DEDMLYSPEL
   241  AQRGHDDDVS STSEDDGYPE DMDQDKHDDS TDDSDTDKSD GESDGDEFVH RDNGERDNNE
   301  EKKSGLSVRF ADMPGKSRKK KKNMKELTPL QAMMLRMAGQ EIPEEGREVE EFSEDDDEDD
   361  SDDSEAEKQS QKQHKEESHS DGTSTASSQQ QAPPQSVPPS QIQAPPMPGP PPLGPPPAPP
   421  LRPPGPPTGL PPGPPPGAPP FLRPPGMPGL RGPLPRLLPP GPPPGRPPGP PPGPPPGLPP
   481  GPPPRGPPPR LPPPAPPGIP PPRPGMMRPP LVPPLGPAPP GLFPPAPLPN PGVLSAPPNL
   541  IQRPKADDTS AATIEKKATA TISAKPQITN PKAEITRFVP TALRVRRENK GATAAPQRKS
   601  EDDSAVPLAK AAPKSGPSVP VSVQTKDDVY EAFMKEMEGL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WBP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 62 nTPM
  • skeletal muscle: 38 nTPM
  • testis: 37 nTPM
  • tongue: 31 nTPM
  • heart muscle: 29 nTPM
  • tonsil: 28 nTPM

Single-cell type

  • late primary spermatocytes: 279 nCPM
  • differentiating spermatogonia: 147 nCPM
  • early primary spermatocytes: 137 nCPM
  • erythrocyte progenitors: 133 nCPM
  • extravillous trophoblasts: 121 nCPM
  • oocytes: 120 nCPM

Immune cell

  • T-reg: 21 nTPM
  • naive CD4 T-cell: 21 nTPM
  • MAIT T-cell: 21 nTPM
  • non-classical monocyte: 21 nTPM
  • naive CD8 T-cell: 20 nTPM
  • intermediate monocyte: 19 nTPM

Brain region

  • hypothalamus: 36 nTPM
  • midbrain: 34 nTPM
  • cerebral cortex: 31 nTPM
  • basal ganglia: 28 nTPM
  • white matter: 27 nTPM
  • pons: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WBP11.

Disease | AllUniProt

Conditions WBP11 is implicated in, by any mechanism.

  • Vertebral, cardiac, tracheoesophageal, renal, and limb defects (VCTRL) MIM:619227

Disease | GeneticClinVar

23 pathogenic / likely-pathogenic of 166 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.15
gnomAD pLI
1
gnomAD missense Z
2.98
DepMap mean gene effect
-1.08
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Wbp11/ELF5/Saf1, N-terminal domain
  • WW domain binding protein 11

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WBP11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WBP11 as an antibody target. Whether an autoantibody or antibody against WBP11 could matter depends on whether native WBP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WBP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WBP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WBP11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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