Seroatlas · Human Serome Atlas

DGCR8

Microprocessor complex subunit DGCR8

Also known as: C22orf12, DGCR8_HUMAN, DGCRK6, Gy1, pasha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WYQ5
Gene
DGCR8
Ensembl
ENSG00000128191
Chromosome
22
Canonical length
773 aa
Protein class
Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

773 residues, UniProt reviewed canonical sequence.

>Q8WYQ5|DGCR8
     1  METDESPSPL PCGPAGEAVM ESRARPFQAL PREQSPPPPL QTSSGAEVMD VGSGGDGQSE
    61  LPAEDPFNFY GASLLSKGSF SKGRLLIDPN CSGHSPRTAR HAPAVRKFSP DLKLLKDVKI
   121  SVSFTESCRS KDRKVLYTGA ERDVRAECGL LLSPVSGDVH ACPFGGSVGD GVGIGGESAD
   181  KKDEENELDQ EKRVEYAVLD ELEDFTDNLE LDEEGAGGFT AKAIVQRDRV DEEALNFPYE
   241  DDFDNDVDAL LEEGLCAPKK RRTEEKYGGD SDHPSDGETS VQPMMTKIKT VLKSRGRPPT
   301  EPLPDGWIMT FHNSGVPVYL HRESRVVTWS RPYFLGTGSI RKHDPPLSSI PCLHYKKMKD
   361  NEEREQSSDL TPSGDVSPVK PLSRSAELEF PLDEPDSMGA DPGPPDEKDP LGAEAAPGAL
   421  GQVKAKVEVC KDESVDLEEF RSYLEKRFDF EQVTVKKFRT WAERRQFNRE MKRKQAESER
   481  PILPANQKLI TLSVQDAPTK KEFVINPNGK SEVCILHEYM QRVLKVRPVY NFFECENPSE
   541  PFGASVTIDG VTYGSGTASS KKLAKNKAAR ATLEILIPDF VKQTSEEKPK DSEELEYFNH
   601  ISIEDSRVYE LTSKAGLLSP YQILHECLKR NHGMGDTSIK FEVVPGKNQK SEYVMACGKH
   661  TVRGWCKNKR VGKQLASQKI LQLLHPHVKN WGSLLRMYGR ESSKMVKQET SDKSVIELQQ
   721  YAKKNKPNLH ILSKLQEEMK RLAEEREETR KKPKMSIVAS AQPGGEPLCT VDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DGCR8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 15 nTPM
  • placenta: 11 nTPM
  • testis: 11 nTPM
  • thymus: 10 nTPM
  • skin: 9.7 nTPM
  • cerebellum: 9.4 nTPM

Single-cell type

  • early spermatids: 101 nCPM
  • adrenal cortex cells: 65 nCPM
  • late spermatids: 64 nCPM
  • podocytes: 46 nCPM
  • rod photoreceptor cells: 45 nCPM
  • myonuclei: 41 nCPM

Immune cell

  • memory CD8 T-cell: 4.3 nTPM
  • MAIT T-cell: 4.2 nTPM
  • non-classical monocyte: 3.7 nTPM
  • naive CD8 T-cell: 3.3 nTPM
  • T-reg: 3.3 nTPM
  • gdT-cell: 2.9 nTPM

Brain region

  • cerebellum: 16 nTPM
  • white matter: 11 nTPM
  • pons: 11 nTPM
  • midbrain: 10 nTPM
  • cerebral cortex: 10 nTPM
  • basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.21
gnomAD pLI
1
gnomAD missense Z
2.99
DepMap mean gene effect
-0.65
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DGCR8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DGCR8 as an antibody target. Whether an autoantibody or antibody against DGCR8 could matter depends on whether native DGCR8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DGCR8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DGCR8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DGCR8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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