Seroatlas · Human Serome Atlas

DCP2

m7GpppN-mRNA hydrolase

Also known as: DCP2_HUMAN, NUDT20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IU60
Gene
DCP2
Ensembl
ENSG00000172795
Chromosome
5
Canonical length
420 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cell Junctions,Cytoplasmic bodies

OverviewNCBI Gene

The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q8IU60|DCP2
     1  METKRVEIPG SVLDDLCSRF ILHIPSEERD NAIRVCFQIE LAHWFYLDFY MQNTPGLPQC
    61  GIRDFAKAVF SHCPFLLPQG EDVEKVLDEW KEYKMGVPTY GAIILDETLE NVLLVQGYLA
   121  KSGWGFPKGK VNKEEAPHDC AAREVFEETG FDIKDYICKD DYIELRINDQ LARLYIIPGI
   181  PKDTKFNPKT RREIRNIEWF SIEKLPCHRN DMTPKSKLGL APNKFFMAIP FIRPLRDWLS
   241  RRFGDSSDSD NGFSSTGSTP AKPTVEKLSR TKFRHSQQLF PDGSPGDQWV KHRQPLQQKP
   301  YNNHSEMSDL LKGKNQSMRG NGRKQYQDSP NQKKRTNGLQ PAKQQNSLMK CEKKLHPRKL
   361  QDNFETDAVY DLPSSSEDQL LEHAEGQPVA CNGHCKFPFS SRAFLSFKFD HNAIMKILDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 17 nTPM
  • bone marrow: 13 nTPM
  • lymph node: 12 nTPM
  • tonsil: 12 nTPM
  • placenta: 11 nTPM
  • spleen: 9.6 nTPM

Single-cell type

  • neutrophils: 485 nCPM
  • neutrophil progenitors: 232 nCPM
  • monocyte progenitors: 162 nCPM
  • tuft cells: 161 nCPM
  • kupffer cells: 146 nCPM
  • microglia: 141 nCPM

Immune cell

  • basophil: 14 nTPM
  • neutrophil: 9.3 nTPM
  • non-classical monocyte: 7.3 nTPM
  • intermediate monocyte: 6.1 nTPM
  • myeloid DC: 5.1 nTPM
  • classical monocyte: 4.9 nTPM

Brain region

  • cerebellum: 27 nTPM
  • hypothalamus: 24 nTPM
  • choroid plexus: 20 nTPM
  • basal ganglia: 18 nTPM
  • cerebral cortex: 18 nTPM
  • pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.66
gnomAD missense Z
0.53
DepMap mean gene effect
-0.38
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCP2 as an antibody target. Whether an autoantibody or antibody against DCP2 could matter depends on whether native DCP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DCP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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