Seroatlas · Human Serome Atlas

ZNF217

Zinc finger protein 217

Also known as: ZABC1, ZN217_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75362
Gene: ZNF217
Ensembl: ENSG00000171940
Chromosome: 20
Canonical length: 1048 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear speckles,Mitochondria

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in mitochondrion and nuclear speck. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1048 residues, UniProt reviewed canonical sequence.

>O75362|ZNF217
     1  MQSKVTGNMP TQSLLMYMDG PEVIGSSLGS PMEMEDALSM KGTAVVPFRA TQEKNVIQIE
    61  GYMPLDCMFC SQTFTHSEDL NKHVLMQHRP TLCEPAVLRV EAEYLSPLDK SQVRTEPPKE
   121  KNCKENEFSC EVCGQTFRVA FDVEIHMRTH KDSFTYGCNM CGRRFKEPWF LKNHMRTHNG
   181  KSGARSKLQQ GLESSPATIN EVVQVHAAES ISSPYKICMV CGFLFPNKES LIEHRKVHTK
   241  KTAFGTSSAQ TDSPQGGMPS SREDFLQLFN LRPKSHPETG KKPVRCIPQL DPFTTFQAWQ
   301  LATKGKVAIC QEVKESGQEG STDNDDSSSE KELGETNKGS CAGLSQEKEK CKHSHGEAPS
   361  VDADPKLPSS KEKPTHCSEC GKAFRTYHQL VLHSRVHKKD RRAGAESPTM SVDGRQPGTC
   421  SPDLAAPLDE NGAVDRGEGG SEDGSEDGLP EGIHLDKNDD GGKIKHLTSS RECSYCGKFF
   481  RSNYYLNIHL RTHTGEKPYK CEFCEYAAAQ KTSLRYHLER HHKEKQTDVA AEVKNDGKNQ
   541  DTEDALLTAD SAQTKNLKRF FDGAKDVTGS PPAKQLKEMP SVFQNVLGSA VLSPAHKDTQ
   601  DFHKNAADDS ADKVNKNPTP AYLDLLKKRS AVETQANNLI CRTKADVTPP PDGSTTHNLE
   661  VSPKEKQTET AADCRYRPSV DCHEKPLNLS VGALHNCPAI SLSKSLIPSI TCPFCTFKTF
   721  YPEVLMMHQR LEHKYNPDVH KNCRNKSLLR SRRTGCPPAL LGKDVPPLSS FCKPKPKSAF
   781  PAQSKSLPSA KGKQSPPGPG KAPLTSGIDS STLAPSNLKS HRPQQNVGVQ GAATRQQQSE
   841  MFPKTSVSPA PDKTKRPETK LKPLPVAPSQ PTLGSSNING SIDYPAKNDS PWAPPGRDYF
   901  CNRSASNTAA EFGEPLPKRL KSSVVALDVD QPGANYRRGY DLPKYHMVRG ITSLLPQDCV
   961  YPSQALPPKP RFLSSSEVDS PNVLTVQKPY GGSGPLYTCV PAGSPASSST LEGKRPVSYQ
  1021  HLSNSMAQKR NYENFIGNAH YRPNDKKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF217 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 29 nTPM
lymph node: 28 nTPM
spleen: 28 nTPM
thymus: 24 nTPM
tonsil: 22 nTPM
breast: 21 nTPM

Single-cell type

ocular epithelial cells: 364 nCPM
neutrophils: 269 nCPM
endometrial glandular cells: 250 nCPM
epididymal clear cells: 206 nCPM
urothelial cells: 200 nCPM
endometrial luminal cells: 161 nCPM

Immune cell

neutrophil: 23 nTPM
non-classical monocyte: 16 nTPM
eosinophil: 11 nTPM
basophil: 9.2 nTPM
intermediate monocyte: 7.5 nTPM
NK-cell: 6.9 nTPM

Brain region

choroid plexus: 20 nTPM
thalamus: 13 nTPM
medulla oblongata: 13 nTPM
midbrain: 13 nTPM
pons: 12 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF217 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF217 as an antibody target. Whether an autoantibody or antibody against ZNF217 could matter depends on whether native ZNF217 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF217 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF217 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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