Seroatlas · Human Serome Atlas

WIZ

Protein Wiz

Also known as: WIZ_HUMAN, ZNF803

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95785
Gene: WIZ
Ensembl: ENSG00000011451
Chromosome: 19
Canonical length: 1651 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; histone methyltransferase binding activity; and transcription corepressor binding activity. Involved in positive regulation of nuclear cell cycle DNA replication and protein stabilization. Located in midbody and nucleoplasm. Biomarker of atherosclerosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1651 residues, UniProt reviewed canonical sequence.

>O95785|WIZ
     1  MEGSLAGSLA APDRPQGPER LPGPAPRENI EGGAEAAEGE GGIFRSTRYL PVTKEGPRDI
    61  LDGRGGISGT PDGRGPWEHP LVQEAGEGIL SERRFEDSVI VRTMKPHAEL EGSRRFLHHR
   121  GEPRLLEKHA QGRPRFDWLQ DEDEQGSPQD AGLHLDLPAQ PPPLAPFRRV FVPVEDTPKT
   181  LDMAVVGGRE DLEDLEGLAQ PSEWGLPTSA SEVATQTWTV NSEASVERLQ PLLPPIRTGP
   241  YLCELLEEVA EGVASPDEDE DEEPAVFPCI ECSIYFKQKE HLLEHMSQHR RAPGQEPPAD
   301  LAPLACGECG WAFADPTALE QHRQLHQASR EKIIEEIQKL KQVPGDEGRE ARLQCPKCVF
   361  GTNSSRAYVQ HAKLHMREPP GQTTKEPFGG SSGAGSPSPE ASALLYQPYG AAVGLSACVF
   421  CGFPAPSESL LREHVRLVHA HPHWEEDGEA YEEDPASQPG TSQDAHACFP DTAVDYFGKA
   481  EPSLAPMWRE NPAGYDPSLA FGPGCQQLSI RDFPLSKPLL HGTGQRPLGR LAFPSTLAST
   541  PYSLQLGRNK STVHPQGLGE RRRPWSEEEE EEEEEEDVVL TSEMDFSPEN GVFSPLATPS
   601  LIPQAALELK QAFREALQAV EATQGQQQQL RGMVPIVLVA KLGPQVMAAA RVPPRLQPEE
   661  LGLAGAHPLD FLLLDAPLGG PLGLDTLLDG DPAMALKHEE RKCPYCPDRF HNGIGLANHV
   721  RGHLNRVGVS YNVRHFISAE EVKAIERRFS FQKKKKKVAN FDPGTFSLMR CDFCGAGFDT
   781  RAGLSSHARA HLRDFGITNW ELTVSPINIL QELLATSAAE QPPSPLGREP GGPPGSFLTS
   841  RRPRLPLTVP FPPTWAEDPG PAYGDAQSLT TCEVCGACFE TRKGLSSHAR SHLRQLGVAE
   901  SESSGAPIDL LYELVKQKGL PDAHLGLPPG LAKKSSSLKE VVAGAPRPGL LSLAKPLDAP
   961  AVNKAIKSPP GFSAKGLGHP PSSPLLKKTP LALAGSPTPK NPEDKSPQLS LSPRPASPKA
  1021  QWPQSEDEGP LNLTSGPEPA RDIRCEFCGE FFENRKGLSS HARSHLRQMG VTEWYVNGSP
  1081  IDTLREILKR RTQSRPGGPP NPPGPSPKAL AKMMGGAGPG SSLEARSPSD LHISPLAKKL
  1141  PPPPGSPLGH SPTASPPPTA RKMFPGLAAP SLPKKLKPEQ IRVEIKREML PGALHGELHP
  1201  SEGPWGAPRE DMTPLNLSSR AEPVRDIRCE FCGEFFENRK GLSSHARSHL RQMGVTEWSV
  1261  NGSPIDTLRE ILKKKSKPCL IKKEPPAGDL APALAEDGPP TVAPGPVQSP LPLSPLAGRP
  1321  GKPGAGPAQV PRELSLTPIT GAKPSATGYL GSVAAKRPLQ EDRLLPAEVK AKTYIQTELP
  1381  FKAKTLHEKT SHSSTEACCE LCGLYFENRK ALASHARAHL RQFGVTEWCV NGSPIETLSE
  1441  WIKHRPQKVG AYRSYIQGGR PFTKKFRSAG HGRDSDKRPS LGLAPGGLAV VGRSAGGEPG
  1501  PEAGRAADGG ERPLAASPPG TVKAEEHQRQ NINKFERRQA RPPDASAARG GEDTNDLQQK
  1561  LEEVRQPPPR VRPVPSLVPR PPQTSLVKFV GNIYTLKCRF CEVEFQGPLS IQEEWVRHLQ
  1621  RHILEMNFSK ADPPPEESQA PQAQTAAAEA P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WIZ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

amygdala: 33 nTPM
cerebral cortex: 32 nTPM
testis: 31 nTPM
hippocampal formation: 27 nTPM
endometrium: 27 nTPM
blood vessel: 25 nTPM

Single-cell type

early primary spermatocytes: 26 nCPM
differentiating spermatogonia: 26 nCPM
alveolar cells type 1: 23 nCPM
esophageal suprabasal cells: 22 nCPM
undifferentiated spermatogonia: 22 nCPM
respiratory deuterosomal cells: 21 nCPM

Immune cell

non-classical monocyte: 1 nTPM
NK-cell: 0.5 nTPM
classical monocyte: 0.3 nTPM
naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
gdT-cell: 0.2 nTPM

Brain region

amygdala: 44 nTPM
hippocampal formation: 43 nTPM
cerebral cortex: 40 nTPM
thalamus: 36 nTPM
basal ganglia: 32 nTPM
midbrain: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.38
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WIZ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WIZ as an antibody target. Whether an autoantibody or antibody against WIZ could matter depends on whether native WIZ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WIZ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WIZ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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