Seroatlas · Human Serome Atlas

IKZF4

Zinc finger protein Eos

Also known as: Eos, IKZF4_HUMAN, ZNFN1A4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2S9
Gene: IKZF4
Ensembl: ENSG00000123411
Chromosome: 12
Canonical length: 585 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q9H2S9|IKZF4
     1  MHTPPALPRR FQGGGRVRTP GSHRQGKDNL ERDPSGGCVP DFLPQAQDSN HFIMESLFCE
    61  SSGDSSLEKE FLGAPVGPSV STPNSQHSSP SRSLSANSIK VEMYSDEESS RLLGPDERLL
   121  EKDDSVIVED SLSEPLGYCD GSGPEPHSPG GIRLPNGKLK CDVCGMVCIG PNVLMVHKRS
   181  HTGERPFHCN QCGASFTQKG NLLRHIKLHS GEKPFKCPFC NYACRRRDAL TGHLRTHSVS
   241  SPTVGKPYKC NYCGRSYKQQ STLEEHKERC HNYLQSLSTE AQALAGQPGD EIRDLEMVPD
   301  SMLHSSSERP TFIDRLANSL TKRKRSTPQK FVGEKQMRFS LSDLPYDVNS GGYEKDVELV
   361  AHHSLEPGFG SSLAFVGAEH LRPLRLPPTN CISELTPVIS SVYTQMQPLP GRLELPGSRE
   421  AGEGPEDLAD GGPLLYRPRG PLTDPGASPS NGCQDSTDTE SNHEDRVAGV VSLPQGPPPQ
   481  PPPTIVVGRH SPAYAKEDPK PQEGLLRGTP GPSKEVLRVV GESGEPVKAF KCEHCRILFL
   541  DHVMFTIHMG CHGFRDPFEC NICGYHSQDR YEFSSHIVRG EHKVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IKZF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 9.3 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 9.3 nTPM
adrenal gland: 8.8 nTPM
retina: 7.8 nTPM
parathyroid gland: 7.6 nTPM
cerebellum: 7.4 nTPM
ovary: 7.3 nTPM

Single-cell type

smooth muscle cells: 50 nCPM
fallopian tube ciliated cells: 48 nCPM
adrenal cortex cells: 42 nCPM
retinal amacrine cells: 33 nCPM
pancreatic islet cells: 33 nCPM
thyrotrophs: 32 nCPM

Immune cell

T-reg: 1.9 nTPM
memory CD4 T-cell: 0.4 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

cerebellum: 12 nTPM
medulla oblongata: 11 nTPM
midbrain: 11 nTPM
thalamus: 11 nTPM
white matter: 10 nTPM
cerebral cortex: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.9
gnomAD missense Z: 2.41
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IKZF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IKZF4 as an antibody target. Whether an autoantibody or antibody against IKZF4 could matter depends on whether native IKZF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IKZF4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IKZF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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