Seroatlas · Human Serome Atlas

NOL4L

Nucleolar protein 4-like

Also known as: C20orf112, C20orf113, dJ1184F4.2, dJ1184F4.4, DKFZP566G1424, NOL4L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MY1
Gene: NOL4L
Ensembl: ENSG00000197183
Chromosome: 20
Canonical length: 436 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q96MY1|NOL4L
     1  MSDSTWMSAD PHLASSLSPS QDERMRSPQN LHSQEDDDSS SESGSGNGSS TLNPSTSSST
    61  QGDPAFPEMN GNGAVAPMDF TTAAEDQPIN LCDKLPPATA LGTASYPSDG CGADGLRSRV
   121  KYGVKTTPES PPYSSGSYDS IKTEVSGCPE DLTVGRAPTA DDDDDDHDDH EDNDKMNDSE
   181  GMDPERLKAF NMFVRLFVDE NLDRMVPISK QPKEKIQAII ESCSRQFPEF QERARKRIRT
   241  YLKSCRRMKK NGMEMTRPTP PHLTSAMAEN ILAAACESET RKAAKRMRLE IYQSSQDEPI
   301  ALDKQHSRDS AAITHSTYSL PASSYSQDPV YANGGLNYSY RGYGALSSNL QPPASLQTGN
   361  HSNGPTDLSM KGGASTTSTT PTPTPSSTST SRPVPTAQLS PTEISAVRQL IAGYRESAAF
   421  LLRSADELEN LILQQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOL4L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

retina: 46 nTPM
testis: 44 nTPM
pituitary gland: 22 nTPM
spinal cord: 21 nTPM
bone marrow: 20 nTPM
cerebellum: 19 nTPM

Single-cell type

corticotrophs: 217 nCPM
late spermatids: 203 nCPM
late primary spermatocytes: 182 nCPM
oocytes: 157 nCPM
megakaryocyte-erythroid progenitors: 156 nCPM
megakaryocyte progenitors: 142 nCPM

Immune cell

non-classical monocyte: 13 nTPM
NK-cell: 8.6 nTPM
naive CD4 T-cell: 8.3 nTPM
T-reg: 7.3 nTPM
naive CD8 T-cell: 7 nTPM
neutrophil: 6.6 nTPM

Brain region

cerebellum: 57 nTPM
white matter: 53 nTPM
cerebral cortex: 49 nTPM
pons: 44 nTPM
medulla oblongata: 42 nTPM
hypothalamus: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 0.99
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of NOL4L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CTBP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOL4L as an antibody target. Whether an autoantibody or antibody against NOL4L could matter depends on whether native NOL4L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOL4L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOL4L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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