Seroatlas · Human Serome Atlas

ZEB1

Zinc finger E-box-binding homeobox 1

Also known as: AREB6, BZP, FECD6, NIL-2-A, PPCD3, TCF8, ZEB, ZEB1_HUMAN, Zfhep, Zfhx1a

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P37275
Gene: ZEB1
Ensembl: ENSG00000148516
Chromosome: 10
Canonical length: 1124 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

1124 residues, UniProt reviewed canonical sequence.

>P37275|ZEB1
     1  MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESVTDA ADCEGVPEDD
    61  LPTDQTVLPG RSSEREGNAK NCWEDDRKEG QEILGPEAQA DEAGCTVKDD ECESDAENEQ
   121  NHDPNVEEFL QQQDTAVIFP EAPEEDQRQG TPEASGHDEN GTPDAFSQLL TCPYCDRGYK
   181  RFTSLKEHIK YRHEKNEDNF SCSLCSYTFA YRTQLERHMT SHKSGRDQRH VTQSGCNRKF
   241  KCTECGKAFK YKHHLKEHLR IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCISLIPVNG
   301  RPRTGLKTSQ CSSPSLSASP GSPTRPQIRQ KIENKPLQEQ LSVNQIKTEP VDYEFKPIVV
   361  ASGINCSTPL QNGVFTGGGP LQATSSPQGM VQAVVLPTVG LVSPISINLS DIQNVLKVAV
   421  DGNVIRQVLE NNQANLASKE QETINASPIQ QGGHSVISAI SLPLVDQDGT TKIIINYSLE
   481  QPSQLQVVPQ NLKKENPVAT NSCKSEKLPE DLTVKSEKDK SFEGGVNDST CLLCDDCPGD
   541  INALPELKHY DLKQPTQPPP LPAAEAEKPE SSVSSATGDG NLSPSQPPLK NLLSLLKAYY
   601  ALNAQPSAEE LSKIADSVNL PLDVVKKWFE KMQAGQISVQ SSEPSSPEPG KVNIPAKNND
   661  QPQSANANEP QDSTVNLQSP LKMTNSPVLP VGSTTNGSRS STPSPSPLNL SSSRNTQGYL
   721  YTAEGAQEEP QVEPLDLSLP KQQGELLERS TITSVYQNSV YSVQEEPLNL SCAKKEPQKD
   781  SCVTDSEPVV NVIPPSANPI NIAIPTVTAQ LPTIVAIADQ NSVPCLRALA ANKQTILIPQ
   841  VAYTYSTTVS PAVQEPPLKV IQPNGNQDER QDTSSEGVSN VEDQNDSDST PPKKKMRKTE
   901  NGMYACDLCD KIFQKSSSLL RHKYEHTGKR PHECGICKKA FKHKHHLIEH MRLHSGEKPY
   961  QCDKCGKRFS HSGSYSQHMN HRYSYCKREA EERDSTEQEE AGPEILSNEH VGARASPSQG
  1021  DSDERESLTR EEDEDSEKEE EEEDKEMEEL QEEKECEKPQ GDEEEEEEEE EVEEEEVEEA
  1081  ENEGEEAKTE GLMKDDRAES QASSLGQKVG ESSEQVSEEK TNEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZEB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

tongue: 57 nTPM
skeletal muscle: 51 nTPM
colon: 47 nTPM
blood vessel: 38 nTPM
smooth muscle: 37 nTPM
endometrium: 36 nTPM

Single-cell type

endometrial stromal cells: 1,976 nCPM
fibro-adipogenic progenitors: 1,444 nCPM
oligodendrocyte progenitor cells: 1,229 nCPM
thyrotrophs: 714 nCPM
myonuclei: 637 nCPM
somatotrophs: 636 nCPM

Immune cell

neutrophil: 8.5 nTPM
naive CD4 T-cell: 6.8 nTPM
NK-cell: 6.6 nTPM
eosinophil: 5.4 nTPM
T-reg: 5 nTPM
basophil: 4.9 nTPM

Brain region

hypothalamus: 47 nTPM
medulla oblongata: 43 nTPM
midbrain: 39 nTPM
thalamus: 37 nTPM
white matter: 36 nTPM
cerebral cortex: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZEB1.

Disease | AllUniProt

Conditions ZEB1 is implicated in, by any mechanism.

Corneal dystrophy, posterior polymorphous, 3 (PPCD3) MIM:609141
Corneal dystrophy, Fuchs endothelial, 6 (FECD6) MIM:613270

Disease | GeneticClinVar

34 pathogenic / likely-pathogenic of 212 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Posterior polymorphous corneal dystrophy 3
Corneal dystrophy, Fuchs endothelial, 6
Corneal dystrophy
Inborn genetic diseases
Posterior polymorphous corneal dystrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 1.6
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZEB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZEB1 as an antibody target. Whether an autoantibody or antibody against ZEB1 could matter depends on whether native ZEB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZEB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZEB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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