Seroatlas · Human Serome Atlas

TGIF1

Homeobox protein TGIF1

Also known as: HPE4, TGIF, TGIF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15583
Gene
TGIF1
Ensembl
ENSG00000177426
Chromosome
18
Canonical length
401 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q15583|TGIF1
     1  MVLAQSRVSA GVGSPHCSGS GGGGSDSFPW PASHPGNPQC SFSTAFLASP RLSRGTLAYL
    61  PPAPWSSLAT PSALLGSSCA PPPPPARCPQ PRALSPELGT KAGPRRPHRW ELPRSPSQGA
   121  QGPAPRRRLL ETMKGIVAAS GSETEDEDSM DIPLDLSSSA GSGKRRRRGN LPKESVQILR
   181  DWLYEHRYNA YPSEQEKALL SQQTHLSTLQ VCNWFINARR RLLPDMLRKD GKDPNQFTIS
   241  RRGAKISETS SVESVMGIKN FMPALEETPF HSCTAGPNPT LGRPLSPKPS SPGSVLARPS
   301  VICHTTVTAL KDVPFSLCQS VGVGQNTDIQ QIAAKNFTDT SLMYPEDTCK SGPSTNTQSG
   361  LFNTPPPTPP DLNQDFSGFQ LLVDVALKRA AEMELQAKLT A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TGIF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
126 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 126 nTPM
  • urinary bladder: 105 nTPM
  • ovary: 83 nTPM
  • fallopian tube: 70 nTPM
  • choroid plexus: 67 nTPM
  • cervix: 65 nTPM

Single-cell type

  • epididymal basal cells: 680 nCPM
  • endometrial glandular cells: 342 nCPM
  • extravillous trophoblasts: 342 nCPM
  • migrating cytotrophoblasts: 295 nCPM
  • basal keratinocytes: 270 nCPM
  • epididymal principal cells: 232 nCPM

Immune cell

  • MAIT T-cell: 68 nTPM
  • basophil: 65 nTPM
  • gdT-cell: 63 nTPM
  • memory CD8 T-cell: 62 nTPM
  • memory CD4 T-cell: 53 nTPM
  • memory B-cell: 47 nTPM

Brain region

  • choroid plexus: 41 nTPM
  • medulla oblongata: 41 nTPM
  • hypothalamus: 41 nTPM
  • spinal cord: 37 nTPM
  • white matter: 36 nTPM
  • midbrain: 36 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TGIF1.

Disease | AllUniProt

Conditions TGIF1 is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 188 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Holoprosencephaly 4

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0.01
gnomAD missense Z
0.18
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TGIF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TGIF1 as an antibody target. Whether an autoantibody or antibody against TGIF1 could matter depends on whether native TGIF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TGIF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TGIF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TGIF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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